The Acute Effect of Two Berry Extracts on Cognition and Mood in Adults Aged 40 to 60

NCT ID: NCT02810769

Last Updated: 2016-06-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-11-30

Study Completion Date

2013-05-31

Brief Summary

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The first study of my PhD showed that acute supplementation of berry extracts can modulate cognitive behaviour in healthy adults. There is a growing body of evidence supporting an improvement in memory and learning performance in animal models following the ingestion of flavonoid rich fruits (Shukitt-Hale et al 2008;Spencer 2008; Spencer et al., 2008). However, study 2, showed no effect on any aspects of memory in healthy young adults after supplementation of the berry extracts. It is hypothesised that the lack of behavioural effects on memory of the berry juice in study 2 was because of the cohort used. These healthy adult participants were already performing near to their peak (Salthouse et al., 2009), and unlike study one, participants were not mentally fatigued enough to reveal subtle cognitive benefits.

The aims of the study are to examine if acute supplementation of two berry extracts in an older population can augment memory, attention and executive function. Secondly, the time course of these behavioural effects will be measured by multiple cognitive assessments throughout the day after consumption of the extracts.

Detailed Description

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Conditions

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Ageing

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Control

Sugar matched control containing no phytochemicals

Group Type PLACEBO_COMPARATOR

Control

Intervention Type DIETARY_SUPPLEMENT

Sugar matched control containing berry flavouring and no phytochemicals

Juiced berry drink

Cold pressed berry drink standardised to contain 500mg of berry polyphenols

Group Type EXPERIMENTAL

Berry drink

Intervention Type DIETARY_SUPPLEMENT

Cold pressed berry drink standardised to contain 500mg of berry polyphenols

Powdered berry drink

Berry drink made up from a powdered concentrate. each drink will be standardised to contain 500mg of polyphenols

Group Type EXPERIMENTAL

Powdered berry drink

Intervention Type DIETARY_SUPPLEMENT

Berry drink made from a powder concentrate standardised to contain 500mg of polyphenols

Interventions

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Berry drink

Cold pressed berry drink standardised to contain 500mg of berry polyphenols

Intervention Type DIETARY_SUPPLEMENT

Control

Sugar matched control containing berry flavouring and no phytochemicals

Intervention Type DIETARY_SUPPLEMENT

Powdered berry drink

Berry drink made from a powder concentrate standardised to contain 500mg of polyphenols

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy
* Non-smokers
* Aged between 40 and 60 years

Exclusion Criteria

* History of neurological, vascular or psychiatric illness.
* BMI greater than 35 kg/m2
* Current diagnosis of depression and/or anxiety.
* History or current diagnosis of drug/alcohol abuse.
* Anaemia.
* Any heart disorder.
* Hypertension
* Any respiratory disorder.
* Diabetes.
* Food intolerances/sensitivities.
* Phenylketonuria.
* Use tobacco products or have ceased in the last 6 months.
* Currently taking, or have taken in the last 2 weeks, any prescribed, illicit or herbal drugs and food supplements.
* Any known active infections.
* HIV antibody positive.
* Currently have, have ever had, or may be at risk of hepatitis.
* Have suffered from jaundice within the last year.
* Have haemophilia or any similar clotting disorder.
* History of head trauma
* History of migraines
* History of learning difficulties
* Any Issues with giving blood samples.
Minimum Eligible Age

40 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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The New Zealand Institute of Plant and Food Research Ltd.

OTHER_GOV

Sponsor Role collaborator

Northumbria University

OTHER

Sponsor Role lead

Responsible Party

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Anthony Watson

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Brain, Performance and Nutrition Research Centre

Newcastle upon Tyne, Newcastle Upon-Tyne, United Kingdom

Site Status

Countries

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United Kingdom

Related Links

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Other Identifiers

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28AI5

Identifier Type: -

Identifier Source: org_study_id

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