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Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

NCT ID: NCT03547102

Last Updated: 2018-06-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-31

Study Completion Date

2016-12-31

Brief Summary

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Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults

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Detailed Description

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The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Cherry concentrate

8 weeks supplementation with montmorency cherry concentrate

Group Type ACTIVE_COMPARATOR

Cherry concentrate

Intervention Type DIETARY_SUPPLEMENT

Placebo concentrate

8 weeks supplementation with placebo isoenergetic cherry concentrate

Group Type PLACEBO_COMPARATOR

Placebo concentrate

Intervention Type DIETARY_SUPPLEMENT

Interventions

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Cherry concentrate

Intervention Type DIETARY_SUPPLEMENT

Placebo concentrate

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* physically inactive consuming 5 or less portions of fruit per day Addenbrookes cognitive examination III score \>88

Exclusion Criteria

* physically active consuming more than 5 portions of fruit per day Addenbrookes cognitive examination III score \<88 Contraindications for MRI
Minimum Eligible Age

60 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Exeter

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Joanna L Bowtell, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Exeter

Other Identifiers

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115229/02

Identifier Type: -

Identifier Source: org_study_id

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