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Effects of Flavonoids on Cognitive Performance in Healthy Young Adults

NCT ID: NCT01312597

Last Updated: 2011-11-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-10-31

Study Completion Date

2011-09-30

Brief Summary

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The purpose of this study is to investigate changes in cerebral blood flow, blood flavonoid levels, brain-derived neurotrophic factor, vascular reactivity and cognitive performance in young adults as a result of acute administration of a fruit-derived flavonoid-rich or flavonoid-poor drink.

Detailed Description

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There has recently been an increasing interest in the potential of flavonoids, plant derived compounds found in foods such as fruit and vegetables, to ameliorate age-related cognitive decline. Research suggests that flavonoids improve memory and learning, possibly as a result of their anti-oxidant, anti-inflammatory and neuroprotective effects for example by increasing cerebral blood flow, protecting vulnerable neurons, enhancing existing neuronal function or by stimulating neuronal function. The research will initially involve a randomised cross-over human dietary intervention trial using two flavonoid-rich drinks (flavanone-rich and flavanone-poor) to investigate changes in cerebral blood flow in young adults (n=6; age range 18-30 years). Changes in cognitive performance and measures of serum BDNF levels will then be investigated in a second randomised cross-over trial using the intervention drink showing the greatest effect on cerebral blood flow in young adults (n=24; age range 18-30 years) and using a range of sensitive tests of executive function. The study is designed to measure acute effects of types of flavonoid supplementation and, as well as the primary cognitive outcome, will assess flavonoid/metabolite and BDNF (brain-derived neurotrophic factor) levels in blood and changes in vascular reactivity.

Conditions

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Neurodegeneration

Keywords

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Flavonoid Cognitive performance Cognitive function Executive function fMRI Cerebral blood flow Acute

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Fruit beverage

Group Type EXPERIMENTAL

Fruit juice beverage

Intervention Type OTHER

500ml fruit juice beverage, single dose per visit

Control beverage

Group Type EXPERIMENTAL

Fruit juice beverage

Intervention Type OTHER

500ml fruit juice beverage, single dose per visit

Interventions

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Fruit juice beverage

500ml fruit juice beverage, single dose per visit

Intervention Type OTHER

Other Intervention Names

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Tropicana Ruby Breakfast Copella English Apple Robinson's Lemon Barley Water

Eligibility Criteria

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Inclusion Criteria

* MMSE between 26 and 30
* 18-30 years of age
* Native or good English speaker
* Normal BMI/body fat composition
* No significant vision, hearing or language problems
* Able to consume the beverages

Exclusion Criteria

* Any form of disease/major mental illness/chronic fatigue syndrome
* On medication for hypertension/elevated lipids/diabetes
* On medication known to impact endothelial function
* Gall bladder/gastrointestinal abnormalities
* Sensitivity to orange or apple
* High consumer of fruit, vegetables, fruit beverages
* High consumer of caffeine or alcohol
* Consumer of illegal substances
* Vegetarian/vegan/other dieter/vigorous exerciser
* Use of antibiotics in the previous 8 weeks
* Consumer of dietary supplements
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Reading

OTHER

Sponsor Role lead

Responsible Party

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Jeremy Paul Edward Spencer

Professor of Biochemistry

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jeremy PE Spencer, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Reading

Locations

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University of Reading

Reading, Berkshire, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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UReading-2011-01

Identifier Type: -

Identifier Source: org_study_id