Effect of Blueberries on Cognition and Body Composition in Elderly With Mild Cognitive Decline
NCT ID: NCT01515098
Last Updated: 2022-03-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
123 participants
INTERVENTIONAL
2012-01-31
2015-03-31
Brief Summary
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Hypothesis 1: Adults with mild cognitive decline who consume blueberries will experience an improvement in cognitive abilities as measured by a standardized battery of tests, relative to those who consume a placebo.
Hypothesis 2: Adults with mild cognitive decline who consume blueberries will evidence an increase in processing speed and an improvement in memory abilities as measured in an electrophysiological paradigm and compared to those who consume a placebo.
Hypothesis 3: Daily intake of 35 g freeze-dried blueberries will improve body composition (fat mass vs. lean mass).
Hypothesis 4: Daily intake of 35 g freeze-dried blueberries will decrease oxidative stress and inflammatory markers.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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Blueberry Group
37 grams of dehydrated blueberries daily for 6 months
Freeze-dried blueberries
Wild blueberries, freeze-dried and pulverized
Placebo Group
37 grams of dextrose powder daily for 6 months
Dextrose Placebo
Placebo developed to closely match blueberry powder.
Reference Group
No intervention
No interventions assigned to this group
Interventions
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Freeze-dried blueberries
Wild blueberries, freeze-dried and pulverized
Dextrose Placebo
Placebo developed to closely match blueberry powder.
Eligibility Criteria
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Inclusion Criteria
* BMI between 18.5 and 34.5
* Close individual to report memory decline
Exclusion Criteria
* Dementia or Alzheimer's diagnosis
* Diabetes
* Smoking \>20 cigarettes/day
* Gastrointestinal/digestive disorders
* Uncontrolled chronic disease
65 Years
79 Years
ALL
Yes
Sponsors
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University of North Carolina, Chapel Hill
OTHER
Responsible Party
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Carol Cheatham, PhD
Assistant Professor of Psychology
Principal Investigators
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Carol L Cheatham, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of North Carolina, Chapel Hill
Locations
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Nutrition Research Institute
Kannapolis, North Carolina, United States
Countries
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References
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Cheatham CL, Canipe LG 3rd, Millsap G, Stegall JM, Chai SC, Sheppard KW, Lila MA. Six-month intervention with wild blueberries improved speed of processing in mild cognitive decline: a double-blind, placebo-controlled, randomized clinical trial. Nutr Neurosci. 2023 Oct;26(10):1019-1033. doi: 10.1080/1028415X.2022.2117475. Epub 2022 Sep 6.
Sheppard KW, Cheatham CL. Omega-6/omega-3 fatty acid intake of children and older adults in the U.S.: dietary intake in comparison to current dietary recommendations and the Healthy Eating Index. Lipids Health Dis. 2018 Mar 9;17(1):43. doi: 10.1186/s12944-018-0693-9.
Other Identifiers
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11-2075
Identifier Type: -
Identifier Source: org_study_id
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