Blueberry Intervention Study for Brain Aging

NCT ID: NCT05024916

Last Updated: 2025-05-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

63 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-06-01

Study Completion Date

2024-10-03

Brief Summary

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The purpose of this study is to determine if increased blueberry intake helps increase brain antioxidant (glutathione) and cerebral blood flow in older adults.

Detailed Description

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Consuming blueberries may improve brain health of older adults by increasing the antioxidant levels in the brain to protect nerve cells in the aging brain. Researchers think that there may be a relationship between the brain's antioxidant defense system and blueberry intake due to the high antioxidant content in blueberries.

This study will investigate if blueberry intake may aid in enhancing glutathione levels and cerebral blood flow using special Magnetic Resonance Imaging (MRI) scans.

Participants will be asked to make a total of up to 4 visits to the research site. Participation will last about 3 months.

Conditions

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Brain Aging

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Intervention

Participants will receive the dietary intervention. Participants will take 1 serving of blueberries/day.

Group Type EXPERIMENTAL

Intervention

Intervention Type DIETARY_SUPPLEMENT

26 g packets of freeze-dried blueberries (equivalent to 1 cup of fresh blueberries) will be given to participants to be consumed daily. Participants will be asked to consume 1 packet per day for 3 months.

Control

Participants will receive a placebo. Participants will take 1 serving of placebo/day.

Group Type ACTIVE_COMPARATOR

Control

Intervention Type DIETARY_SUPPLEMENT

26 g packets of isocaloric carbohydrate-matched powder will be given to participants to be consumed daily. Participants will be asked to consume 1 packet/day for 3 months.

Interventions

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Intervention

26 g packets of freeze-dried blueberries (equivalent to 1 cup of fresh blueberries) will be given to participants to be consumed daily. Participants will be asked to consume 1 packet per day for 3 months.

Intervention Type DIETARY_SUPPLEMENT

Control

26 g packets of isocaloric carbohydrate-matched powder will be given to participants to be consumed daily. Participants will be asked to consume 1 packet/day for 3 months.

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Freeze-dried blueberries Placebo

Eligibility Criteria

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Inclusion Criteria

* Speak English as the primary language and be able to read and write.
* Good general health with no concomitant diseases
* Low berry consumption (≤1 serving/week)
* Cognitively normal (Mini-Mental State Exam Score ≥24)
* BMI range=18.5-35 kg/m2.

Exclusion Criteria

* Presence of any central neurological diseases or prior major head trauma with loss of consciousness
* Presence of an active unstable and life-threatening systemic illness
* Presence of major psychiatric disorders within the past 3 years including depression, anxiety, and alcohol or drug abuse
* Presence of diabetes mellitus; metabolic syndrome or uncontrolled hypertension
* Use of psychoactive and investigational medications
* MRI contraindications (pacemaker, aneurysm clips, artificial heart valves, metal fragments, foreign objects or claustrophobia)
* Blueberry or salicylate allergy
* Pregnancy
Minimum Eligible Age

65 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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U.S. Highbush Blueberry Council

OTHER

Sponsor Role collaborator

University of Kansas Medical Center

OTHER

Sponsor Role lead

Responsible Party

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In-Young Choi, Ph.D.

Professor of Neurology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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In-Young Choi, PhD

Role: PRINCIPAL_INVESTIGATOR

Department of Neurology

Locations

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University of Kansas Medical Center

Kansas City, Kansas, United States

Site Status

Countries

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United States

Other Identifiers

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STUDY00147614

Identifier Type: -

Identifier Source: org_study_id

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