Dose-dependent Effects of Blueberry Polyphenols on Endothelial Function in Healthy Individuals
NCT ID: NCT01829542
Last Updated: 2013-04-11
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
11 participants
INTERVENTIONAL
2012-05-31
2012-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
QUADRUPLE
Study Groups
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319 mg blueberry polyphenols
Freeze-dried blueberry powder dissolved in water
Freeze-dried blueberry powder dissolved in water
Wild blueberry freeze-dried powder dissolved in water
639 mg blueberry polyphenols
Freeze-dried blueberry powder dissolved in water
Freeze-dried blueberry powder dissolved in water
Wild blueberry freeze-dried powder dissolved in water
766 mg blueberry polyphenols
Freeze-dried blueberry powder dissolved in water
Freeze-dried blueberry powder dissolved in water
Wild blueberry freeze-dried powder dissolved in water
1466 mg blueberry polyphenols
Freeze-dried blueberry powder dissolved in water
Freeze-dried blueberry powder dissolved in water
Wild blueberry freeze-dried powder dissolved in water
1791 mg total blueberry polyphenols
Freeze-dried blueberry powder dissolved in water
Freeze-dried blueberry powder dissolved in water
Wild blueberry freeze-dried powder dissolved in water
O mg blueberry polyphenols
Macro- and micronutrient matched control drink
Control
Macro- and micro-nutrient matched control in water
Interventions
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Freeze-dried blueberry powder dissolved in water
Wild blueberry freeze-dried powder dissolved in water
Control
Macro- and micro-nutrient matched control in water
Eligibility Criteria
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Inclusion Criteria
* 18-40 years
* Healthy
* signed consent form
Exclusion Criteria
* Had suffered a myocardial infarction or stroke
* Suffers from any blood-clotting disorder
* Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases)
* Any dietary restrictions or on a weight reducing diet
* Allergies or intolerances to any foods
* Smoker
* Heavy drinker (\>21 units per week)
* On any lipid-modifying medication
* On any blood pressure lowering medication
* On any medication affecting blood clotting
* Taking high dose fish oil supplements (greater then 1 g EPA and DHA per day) or high doses of antioxidant vitamins (greater then 800 μg vitamin A, 60 mg vitamin C, 10 mg vitamin E or 400 μg beta carotene)
* Taking probiotics, prebiotics, synbiotics, antibiotics or anti-inflammatory or blood lowering medication within a 2-month period prior to the study
* Planning on altering consumption of vitamin supplements/fish oil capsules during the course of the study
* Undertakes strenuous exercise \> 4 times per week for \> 1 hour per session
* Haemoglobin levels below reference range provided by the Royal Berkshire Hospital
18 Years
40 Years
MALE
Yes
Sponsors
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Alpro Foundation
OTHER
University of Reading
OTHER
Responsible Party
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Jeremy Paul Edward Spencer
Professor
Locations
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Hugh Sinclair Unit of Human Nutrition
Reading, Berkshire, United Kingdom
Countries
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References
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Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Heiss C, Spencer JP. Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr. 2013 Nov;98(5):1179-91. doi: 10.3945/ajcn.113.066639. Epub 2013 Sep 4.
Other Identifiers
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BB2UReading
Identifier Type: -
Identifier Source: org_study_id
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