Anthocyanin-rich Blackcurrant and Vascular Function

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

23 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-06-30

Study Completion Date

2015-11-30

Brief Summary

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Regular consumption of fruits and vegetables may improve human health and reduce the risk of chronic diseases, such as heart disease, certain cancers and type 2 diabetes, but the active components and the underlying mechanisms are poorly understood. Berry fruits are abundant in anthocyanins and this study aims to test the hypothesis that ingestion of an anthocyanin-rich blackcurrant beverage will improve markers of cardiovascular health (health of blood vessels, inflammation and platelet function). Further, the study will investigate the anthocyanin bioavailability from the blackcurrant beverage.

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Detailed Description

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Conditions

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Vascular Stiffness Inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Intervention

Spray dried blackcurrant powder dissolved in water

Group Type ACTIVE_COMPARATOR

Beverage: Spray dried blackcurrant powder dissolved in water

Intervention Type OTHER

Placebo

(sucrose, glucose, fructose, maltodextrin, malic acid, citric acid, vitamin C, artificial blackcurrant flavouring and low-nitrate water)

Group Type PLACEBO_COMPARATOR

Beverage: Placebo (sucrose, glucose, fructose, maltodextrin, malic acid, citric acid, vitamin C, artificial blackcurrant flavouring and low-nitrate water)

Intervention Type OTHER

Interventions

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Beverage: Spray dried blackcurrant powder dissolved in water

Intervention Type OTHER

Beverage: Placebo (sucrose, glucose, fructose, maltodextrin, malic acid, citric acid, vitamin C, artificial blackcurrant flavouring and low-nitrate water)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Aged 30-55 years
* Non-smoker
* BMI between 20 - 30 kg/m2
* Generally healthy as established by a 'health and lifestyle' questionnaire and a screening blood sample
* Blood pressure \< 140/90mmHg
* Total cholesterol \< 6.2 mmol/L
* Fasting glucose \< 7.0 mmol/L

Exclusion Criteria

* Diabetes mellitus
* Heart problems, stroke, vascular disease
* Inflammatory disease
* Kidney, liver, pancreas or gastrointestinal diseases
* Medication for hyperlipidaemia, hypertension, hypercoagulation, inflammatory conditions
* Asthma
* Allergies
* Smokers (social smokers who agree to abstain for 1 month before and during the study not excluded)
* Taking phytochemical, antioxidant or fish oil supplements (unless willing to stop for the study period)
* Taking aspirin \> 2 times per month and unwilling to abstain from aspirin ingestion for 14 days prior each study visit
* History of alcohol misuse
* Consumption of alcohol \>21 units (men) or \>15 units (women)
* Vegans
* Intense aerobic exercise \>20 min 3 x per week
* Participation in another clinical trial
* Antibiotics in previous 3 months before study
* Low haemoglobin levels
* Females who are pregnant, lactating, or if of reproductive age and not using a reliable form of contraception (including abstinence)

Minimum Eligible Age

30 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes