Effects of a Beverage Rich in Fruit Extracts on Risk Factors Associated With Cardiovascular Disease
NCT ID: NCT00795834
Last Updated: 2008-11-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
40 participants
INTERVENTIONAL
2008-06-30
2009-03-31
Brief Summary
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Detailed Description
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Novel risk factors for vascular disease will be assessed including non-invasive assessment of vascular function by pulse wave analysis / pulse wave velocity and laser doppler iontophoresis.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
QUADRUPLE
Study Groups
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Beverage
Placebo Beverage
Antioxidant capacity umol TE/L(ORAC): negligible Polyphenolic Content(mcg/ml): negligible Vitamin C (mg/100ml): 0.00 Calorie Content (Kcal/250ml):40.0
250ml twice daily for 1 month (56 doses)
High Polyphenol Beverage
High polyphenol beverage
Antioxidant capacity umol TE/L(ORAC): 19987 Polyphenolic Content(mcg/ml): 1445 Vitamin C (mg/100ml): 35.35 Calorie Content (Kcal/250ml):40.0
250ml twice daily for 1 month (56 doses)
Interventions
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High polyphenol beverage
Antioxidant capacity umol TE/L(ORAC): 19987 Polyphenolic Content(mcg/ml): 1445 Vitamin C (mg/100ml): 35.35 Calorie Content (Kcal/250ml):40.0
250ml twice daily for 1 month (56 doses)
Placebo Beverage
Antioxidant capacity umol TE/L(ORAC): negligible Polyphenolic Content(mcg/ml): negligible Vitamin C (mg/100ml): 0.00 Calorie Content (Kcal/250ml):40.0
250ml twice daily for 1 month (56 doses)
Eligibility Criteria
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Inclusion Criteria
* BMI \> 25
Exclusion Criteria
* HBA1C \> 6.0%
* eGFR\<60
* LFT \>/= 3 times upper limit of normal
* Hypertension: systolic blood pressure \> 160mmHg; diastolic blood pressure \> 90mmHg, or on medication for hypertension.
* Chronic disease, likely to be clinically relevant (eg:
cardiorespiratory, rheumatological, cerebrovascular or neoplastic disease)
* Vitamin supplements within the previous 14 days
* Medications which, in the opinion of the investigators, are known to influence vascular function (eg corticosteroids).
55 Years
ALL
Yes
Sponsors
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University of Glasgow
OTHER
Responsible Party
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University of Glasgow
Principal Investigators
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Naveed Sattar, MBChB PhD FRCPath FRCP
Role: PRINCIPAL_INVESTIGATOR
University of Glasgow
Locations
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British Heart Foundation Glasgow Cardiovascular Research Centre
Glasgow, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Adam Mullan, MBChB BSc MRCP
Role: primary
References
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Mullan A, Delles C, Ferrell W, Mullen W, Edwards CA, McColl JH, Roberts SA, Lean ME, Sattar N. Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial. Atherosclerosis. 2016 Mar;246:169-76. doi: 10.1016/j.atherosclerosis.2016.01.004. Epub 2016 Jan 6.
Other Identifiers
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RN08BI013
Identifier Type: -
Identifier Source: secondary_id
07/S0704/110
Identifier Type: -
Identifier Source: org_study_id