Dietary Wild Blueberries and Joint Health

NCT ID: NCT06828159

Last Updated: 2025-11-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-09-01

Study Completion Date

2028-03-31

Brief Summary

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The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.

Detailed Description

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Conditions

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Gut -Microbiota Inflammation Biomarkers Pain Assessment Joint Pain

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Wild blueberries

25g freeze-dried wild blueberries daily for 12 weeks

Group Type EXPERIMENTAL

Wild blueberry

Intervention Type DIETARY_SUPPLEMENT

Freeze-dried wild blueberry powder 25g/day

Placebo

Placebo powder free from polyphenols matched for calories

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Placebo powder matched for calories and no polyphenols

Interventions

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Wild blueberry

Freeze-dried wild blueberry powder 25g/day

Intervention Type DIETARY_SUPPLEMENT

Placebo

Placebo powder matched for calories and no polyphenols

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Adults with documented multi-joint/knee arthritis

Exclusion Criteria

* inability to give informed consent
* pregnancy or lactation
* planned knee replacement surgery
* allergy or contraindication to berries
* recent trauma of the knee responsible of the symptomatic knee
* intra-articular injection in the target knee/hip in the last 3 months
* oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
* use of berry extracts in the last 3 months
* special diets
* cancer treatment
* bone diseases
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Oklahoma Medical Research Foundation

OTHER

Sponsor Role collaborator

University of Nevada, Las Vegas

OTHER

Sponsor Role lead

Responsible Party

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Arpita Basu

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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OMRF

Oklahoma City, Oklahoma, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Arpita Basu

Role: CONTACT

702-895-4576

Facility Contacts

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Judy Goodman

Role: primary

405- 271-3007

Other Identifiers

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WBANA01

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

OMRF WB01

Identifier Type: -

Identifier Source: org_study_id

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