Effects of Freeze-dried Grape Powder on Immune Profiles in Healthy Aging Adults
NCT ID: NCT07079982
Last Updated: 2025-07-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
28 participants
INTERVENTIONAL
2025-07-25
2027-09-30
Brief Summary
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The main study procedures include consumption of a freeze-dried grape powder and control powder (which tastes the same but has none of the grape compounds that are being studied) mixed with water as a beverage on a daily basis for 4 weeks each. The investigators will additionally ask that participants avoid eating grapes and certain other antioxidant/grape-related foods and beverages throughout the 13-week study. Participants will additionally be asked to complete surveys about their diet, physical activity, and medical history, as well as provide blood samples and body weight measures throughout the course of the study. Participation in the study is expected to last about 6.25 hours over the course of 13 weeks and will include 7 visits.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Freeze-dried whole grape powder
Freeze-dried whole grape powder
Studying the effects of freeze-dried whole grape powder on immune profiles in healthy aging adults
Control grape-free powder
Control grape-free powder
Studying effects of a control grape-free powder on immune profiles in healthy aging
Interventions
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Freeze-dried whole grape powder
Studying the effects of freeze-dried whole grape powder on immune profiles in healthy aging adults
Control grape-free powder
Studying effects of a control grape-free powder on immune profiles in healthy aging
Eligibility Criteria
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Inclusion Criteria
* Body mass index (BMI) 18.5 to \< 30 kg/m2
* Willing to consume grape and control powder during study periods, and refrain from eating grapes and certain other polyphenol-rich foods and beverages during the study
Exclusion Criteria
* BMI \<18.5 and ≥ 30 kg/m2 or body weight \< 110 pounds
* Experienced \>10% weight change in the past 4 weeks
* Elevated fasting glucose levels (fasting glucose higher than 126 mg/dL) and triglycerides greater than 500 mg/dL
* Self-reported and/or physician-diagnosed history of diabetes mellitus, coronary heart disease, stroke, renal or liver disease, cancer, eating disorders, certain severe and/or relapsing/remitting autoimmune, inflammatory, or metabolic diseases, chronic infections, scleroderma, blood clotting disorders, intravenous drug use, or current pregnancy or lactation
* Allergy to grapes or any ingredients in the grape or control powders
* Implanted medical device (e.g., pacemaker) or other health condition that would prevent measurement of body composition by bioelectrical impedance
* Currently taking lipid-lowering medications (e.g., statins, fibrates), glucose-regulating medications, anti-inflammatory medications (e.g., non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids), or medications that primarily affect blood clotting (e.g., warfarin), long-term antibiotics in the last 3 months, active use of probiotics during the intervention
* Active smoker
50 Years
75 Years
ALL
Yes
Sponsors
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University of Connecticut
OTHER
Responsible Party
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Catherine Andersen
Associate Professor
Locations
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Department of Nutritional Sciences
Storrs, Connecticut, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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B2024-0072/24-02-508-910
Identifier Type: -
Identifier Source: org_study_id
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