Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-07-31

Study Completion Date

2010-12-31

Brief Summary

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The purpose of this study is to determine the effects of a single dose of cranberry beverage in healthy adults on the kinetic uptake of polyphenol compounds and polyphenol metabolites, and antioxidative and anti-inflammatory activity.

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Detailed Description

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Participants will be randomized based on age, sex and BMI, and will consume a low-polyphenol diet 2 days prior to the intervention. On the day of the study, baseline blood and urine samples will be collected after an overnight fast. Participants will consume the assigned beverage within 15 minutes and blood collected at 2, 4, 8, and 24 h (10 mL/blood draw; total blood volume per period = 50 mL). Urine will be collected for polyphenol analysis during the following periods: 0-3, 3-6, 6-9, 9-12, 12-24 hours. After a one-week washout period, participants will receive their second and then the third beverage in a cross-over design; blood and urine sampling will be repeated at each of the 3 intervention periods.

Conditions

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Inflammation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Low Calorie Cranberry Juice Cocktail

Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes

Group Type ACTIVE_COMPARATOR

Low Calorie Cranberry Juice Cocktail

Intervention Type OTHER

Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes

Cranberry Extract Beverage

Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes

Group Type ACTIVE_COMPARATOR

Cranberry Extract Beverage

Intervention Type OTHER

Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes

Non-Cranberry Beverage

Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes

Group Type PLACEBO_COMPARATOR

Non-Cranberry Beverage

Intervention Type OTHER

Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes

Interventions

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Low Calorie Cranberry Juice Cocktail

Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes

Intervention Type OTHER

Cranberry Extract Beverage

Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes

Intervention Type OTHER

Non-Cranberry Beverage

Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Men \& women; aged 18-35 years
* BMI: 19-25 kg/m2

Exclusion Criteria

* Any significant chronic disease, hypertension, ulcers, dyspepsia, lactose intolerance, allergy, psychotic illness
* Had major gastrointestinal surgery or on prescription or surgical treatment
* Any condition that may interfere with the digestion, absorption, metabolism or excretion of nutrients
* Regularly smoked in the previous 6 months
* On medication or ingested a prescribed drug at any time within the 14 days preceding study enrolment (excluding hormonal contraceptives and hormone replacement therapy) or over-the-counter preparation within 7 days preceding enrolment
* Risk factors for AIDS or known HIV positive status
* Pregnant or lactating
* High intake of chocolate or similar high polyphenol foods
* Regular intake of vitamin and polyphenol supplements
* Drug and alcohol misuse
* Currently participating or had participated in another clinical study during the previous 3 weeks
* Donated blood in the previous 3 weeks
* Exercise more than 3 times/week for longer than 45 min each time

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes