To Determine the Activity and Mechanisms of Cranberries to Attenuate Skin Photoaging and Improve Skin Health in Women
NCT ID: NCT04183920
Last Updated: 2024-07-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
22 participants
INTERVENTIONAL
2020-02-07
2024-07-10
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
TRIPLE
Study Groups
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Group A
Participants in this arm will be provided cranberry juice to consume for 42 days in total. After a 10-21-day washout period participants will receive placebo juice for 42 days.
Cranberry juice
cranberry juice cocktail provided by Ocean Spray Cranberries, Inc.
Placebo juice
apple juice added with flavor and colorants provided by Ocean Spray Cranberries, Inc.
Group B
Participants in this arm will be provided placebo juice to consume for 42 days in total. After a 10-21-day washout period participants will receive cranberry juice to consume for 42 days
Cranberry juice
cranberry juice cocktail provided by Ocean Spray Cranberries, Inc.
Placebo juice
apple juice added with flavor and colorants provided by Ocean Spray Cranberries, Inc.
Interventions
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Cranberry juice
cranberry juice cocktail provided by Ocean Spray Cranberries, Inc.
Placebo juice
apple juice added with flavor and colorants provided by Ocean Spray Cranberries, Inc.
Eligibility Criteria
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Inclusion Criteria
* BMI (18.5-29.9)
* Body weight ≥110 pounds
Exclusion Criteria
* Smokers and frequent alcohol use
* Pregnancy
* Breast-feeding
* intake of medication that might influence the outcome of the study
* sunbathing or the use of tanning bed
* intake of vitamin/mineral supplements
21 Years
65 Years
FEMALE
Yes
Sponsors
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Ocean Spray, Inc.
INDUSTRY
University of Florida
OTHER
Responsible Party
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Principal Investigators
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Liwei Gu, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Florida
Locations
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Food Science and human nutrition department at University of Florida
Gainesville, Florida, United States
Countries
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References
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Ramasamy R, Yan SF, Schmidt AM. Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. Ann N Y Acad Sci. 2011 Dec;1243:88-102. doi: 10.1111/j.1749-6632.2011.06320.x.
Liu H, Liu H, Wang W, Khoo C, Taylor J, Gu L. Cranberry phytochemicals inhibit glycation of human hemoglobin and serum albumin by scavenging reactive carbonyls. Food Funct. 2011 Aug;2(8):475-82. doi: 10.1039/c1fo10087d. Epub 2011 Aug 8.
Heinrich U, Moore CE, De Spirt S, Tronnier H, Stahl W. Green tea polyphenols provide photoprotection, increase microcirculation, and modulate skin properties of women. J Nutr. 2011 Jun;141(6):1202-8. doi: 10.3945/jn.110.136465. Epub 2011 Apr 27.
Heinrich U, Neukam K, Tronnier H, Sies H, Stahl W. Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. J Nutr. 2006 Jun;136(6):1565-9. doi: 10.1093/jn/136.6.1565.
Other Identifiers
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IRB201903250
Identifier Type: -
Identifier Source: org_study_id
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