Trial Outcomes & Findings for Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress (NCT NCT01780922)
NCT ID: NCT01780922
Last Updated: 2014-07-08
Results Overview
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
12 participants
Primary outcome timeframe
0, 2, 4, 8, 24 h
Results posted on
2014-07-08
Participant Flow
Participant milestones
| Measure |
LCJC First, Then CLEB, Then Placebo
First Intervention (1 day) - Low Calorie Cranberry Juice Cocktail (LCJC): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Second Intervention (1 day) - Cranberry Leaf Extract Beverage (CLEB): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Third Intervention (1 day) - Placebo: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
LCJC First, Then Placebo, Then CLEB
First Intervention (1 day) - Low Calorie Cranberry Juice Cocktail (LCJC): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Second Intervention (1 day) - Placebo: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Third Intervention (1 day) - Cranberry Leaf Extract Beverage (CLEB): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
CLEB First, Then LCJC, Then Placebo
First Intervention (1 day) - Cranberry Leaf Extract Beverage (CLEB): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Second Intervention (1 day) - Low Calorie Cranberry Juice Cocktail (LCJC): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Third Intervention (1 day) - Placebo: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
CLEB First, Then Placebo, Then LCJC
First Intervention (1 day) - Cranberry Leaf Extract Beverage (CLEB): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Second Intervention (1 day) - Placebo: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Third Intervention (1 day) - Low Calorie Cranberry Juice Cocktail (LCJC): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Placebo First, Then LCJC, Then CLEB
First Intervention (1 day) - Placebo: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Second Intervention (1 day) - Low Calorie Cranberry Juice Cocktail (LCJC): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Third Intervention (1 day) - Cranberry Leaf Extract Beverage (CLEB): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Placebo First, Then CLEB, Then LCJC
First Intervention (1 day) - Placebo: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Second Intervention (1 day) - Cranberry Leaf Extract Beverage (CLEB): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes Washout (7 days) Third Intervention (1 day) - Low Calorie Cranberry Juice Cocktail (LCJC): Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|---|---|---|
|
First Intervention (1 Day)
STARTED
|
2
|
2
|
2
|
2
|
2
|
2
|
|
First Intervention (1 Day)
COMPLETED
|
2
|
2
|
2
|
2
|
2
|
2
|
|
First Intervention (1 Day)
NOT COMPLETED
|
0
|
0
|
0
|
0
|
0
|
0
|
|
Washout (7 Days)
STARTED
|
2
|
2
|
2
|
2
|
2
|
2
|
|
Washout (7 Days)
COMPLETED
|
2
|
2
|
2
|
2
|
2
|
2
|
|
Washout (7 Days)
NOT COMPLETED
|
0
|
0
|
0
|
0
|
0
|
0
|
|
Second Intervention (1 Day)
STARTED
|
2
|
2
|
2
|
2
|
2
|
2
|
|
Second Intervention (1 Day)
COMPLETED
|
2
|
2
|
2
|
2
|
2
|
2
|
|
Second Intervention (1 Day)
NOT COMPLETED
|
0
|
0
|
0
|
0
|
0
|
0
|
|
Third Intervention (1 Day)
STARTED
|
2
|
2
|
2
|
2
|
2
|
2
|
|
Third Intervention (1 Day)
COMPLETED
|
2
|
2
|
2
|
2
|
2
|
2
|
|
Third Intervention (1 Day)
NOT COMPLETED
|
0
|
0
|
0
|
0
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress
Baseline characteristics by cohort
| Measure |
All Study Participants
n=12 Participants
All study participants: all participants received all interventions
|
|---|---|
|
Age, Continuous
|
27.5 years
STANDARD_DEVIATION 4.3 • n=5 Participants
|
|
Sex: Female, Male
Female
|
6 Participants
n=5 Participants
|
|
Sex: Female, Male
Male
|
6 Participants
n=5 Participants
|
|
Body Mass Index
|
23.7 kg/m^2
STANDARD_DEVIATION 3.0 • n=5 Participants
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Reduced Glutathione (GSH) Concentrations in Red Blood Cells
GSH at 0h
|
1.38 mmol/L
Standard Error 0.13
|
1.22 mmol/L
Standard Error 0.14
|
1.23 mmol/L
Standard Error 0.04
|
|
Reduced Glutathione (GSH) Concentrations in Red Blood Cells
GSH at 2h
|
1.12 mmol/L
Standard Error 0.12
|
1.24 mmol/L
Standard Error 0.07
|
1.26 mmol/L
Standard Error 0.05
|
|
Reduced Glutathione (GSH) Concentrations in Red Blood Cells
GSH at 4h
|
1.39 mmol/L
Standard Error 0.08
|
1.26 mmol/L
Standard Error 0.09
|
1.30 mmol/L
Standard Error 0.04
|
|
Reduced Glutathione (GSH) Concentrations in Red Blood Cells
GSH at 8h
|
1.40 mmol/L
Standard Error 0.08
|
1.26 mmol/L
Standard Error 0.08
|
1.28 mmol/L
Standard Error 0.16
|
|
Reduced Glutathione (GSH) Concentrations in Red Blood Cells
GSH at 24h
|
1.58 mmol/L
Standard Error 0.13
|
1.26 mmol/L
Standard Error 0.06
|
1.31 mmol/L
Standard Error 0.05
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Superoxide Dismutase (SOD) Activity in Red Blood Cells
SOD at 0h
|
19.0 mU/mg HgB
Standard Error 2.0
|
17.6 mU/mg HgB
Standard Error 1.0
|
20.3 mU/mg HgB
Standard Error 1.7
|
|
Superoxide Dismutase (SOD) Activity in Red Blood Cells
SOD at 2h
|
19.6 mU/mg HgB
Standard Error 1.2
|
17.1 mU/mg HgB
Standard Error 1.4
|
20.7 mU/mg HgB
Standard Error 1.2
|
|
Superoxide Dismutase (SOD) Activity in Red Blood Cells
SOD at 4h
|
20.9 mU/mg HgB
Standard Error 1.0
|
22.7 mU/mg HgB
Standard Error 1.4
|
19.5 mU/mg HgB
Standard Error 1.0
|
|
Superoxide Dismutase (SOD) Activity in Red Blood Cells
SOD at 8h
|
16.8 mU/mg HgB
Standard Error 1.7
|
20.2 mU/mg HgB
Standard Error 1.2
|
18.2 mU/mg HgB
Standard Error 3.3
|
|
Superoxide Dismutase (SOD) Activity in Red Blood Cells
SOD at 24h
|
19.2 mU/mg HgB
Standard Error 1.3
|
18.4 mU/mg HgB
Standard Error 0.7
|
14.6 mU/mg HgB
Standard Error 1.4
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Glutathione Peroxidase (GPx) Activity in Red Blood Cells
GPx at 0h
|
174 mU/mg HgB
Standard Error 14
|
161 mU/mg HgB
Standard Error 9
|
163 mU/mg HgB
Standard Error 16
|
|
Glutathione Peroxidase (GPx) Activity in Red Blood Cells
GPx at 2h
|
169 mU/mg HgB
Standard Error 12
|
185 mU/mg HgB
Standard Error 12
|
149 mU/mg HgB
Standard Error 14
|
|
Glutathione Peroxidase (GPx) Activity in Red Blood Cells
GPx at 4h
|
185 mU/mg HgB
Standard Error 14
|
197 mU/mg HgB
Standard Error 15
|
200 mU/mg HgB
Standard Error 15
|
|
Glutathione Peroxidase (GPx) Activity in Red Blood Cells
GPx at 8h
|
179 mU/mg HgB
Standard Error 18
|
183 mU/mg HgB
Standard Error 9
|
170 mU/mg HgB
Standard Error 29
|
|
Glutathione Peroxidase (GPx) Activity in Red Blood Cells
GPx at 24h
|
181 mU/mg HgB
Standard Error 15
|
172 mU/mg HgB
Standard Error 12
|
192 mU/mg HgB
Standard Error 17
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Oxidative Damage to DNA Assessed by Plasma 8-hydroxy-2'-Deoxyguanosine (8-OHdG)
8OHdG at 0h
|
30.7 ng/mL
Standard Error 7.9
|
33.6 ng/mL
Standard Error 10.1
|
29.2 ng/mL
Standard Error 6.4
|
|
Oxidative Damage to DNA Assessed by Plasma 8-hydroxy-2'-Deoxyguanosine (8-OHdG)
8OHdG at 2h
|
36.5 ng/mL
Standard Error 13.3
|
31.0 ng/mL
Standard Error 8.2
|
34.6 ng/mL
Standard Error 9.9
|
|
Oxidative Damage to DNA Assessed by Plasma 8-hydroxy-2'-Deoxyguanosine (8-OHdG)
8OHdG at 4h
|
31.2 ng/mL
Standard Error 8.8
|
33.5 ng/mL
Standard Error 9.1
|
29.8 ng/mL
Standard Error 6.1
|
|
Oxidative Damage to DNA Assessed by Plasma 8-hydroxy-2'-Deoxyguanosine (8-OHdG)
8OHdG at 8h
|
34.4 ng/mL
Standard Error 9.7
|
31.5 ng/mL
Standard Error 7.5
|
31.5 ng/mL
Standard Error 9.0
|
|
Oxidative Damage to DNA Assessed by Plasma 8-hydroxy-2'-Deoxyguanosine (8-OHdG)
8OHdG at 24h
|
35.1 ng/mL
Standard Error 10.5
|
32.7 ng/mL
Standard Error 9.0
|
34.6 ng/mL
Standard Error 10.8
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
C-Reactive Protein (CRP) Concentrations in Plamsa
CRP at 0h
|
1.10 ug/mL
Standard Error 0.26
|
1.18 ug/mL
Standard Error 0.34
|
0.87 ug/mL
Standard Error 0.15
|
|
C-Reactive Protein (CRP) Concentrations in Plamsa
CRP at 2h
|
0.85 ug/mL
Standard Error 0.21
|
1.03 ug/mL
Standard Error 0.31
|
0.99 ug/mL
Standard Error 0.24
|
|
C-Reactive Protein (CRP) Concentrations in Plamsa
CRP at 4h
|
0.69 ug/mL
Standard Error 0.21
|
0.81 ug/mL
Standard Error 0.20
|
0.96 ug/mL
Standard Error 0.17
|
|
C-Reactive Protein (CRP) Concentrations in Plamsa
CRP at 8h
|
1.04 ug/mL
Standard Error 0.26
|
1.07 ug/mL
Standard Error 0.26
|
0.99 ug/mL
Standard Error 0.18
|
|
C-Reactive Protein (CRP) Concentrations in Plamsa
CRP at 24h
|
1.28 ug/mL
Standard Error 0.22
|
0.93 ug/mL
Standard Error 0.20
|
0.97 ug/mL
Standard Error 0.21
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Nitric Oxide (NO) Concentrations in Plamsa
NO at 0h
|
14.9 umol/L
Standard Error 1.8
|
16.6 umol/L
Standard Error 4.1
|
13.1 umol/L
Standard Error 1.4
|
|
Nitric Oxide (NO) Concentrations in Plamsa
NO at 2h
|
13.0 umol/L
Standard Error 1.2
|
15.3 umol/L
Standard Error 3.4
|
12.2 umol/L
Standard Error 1.1
|
|
Nitric Oxide (NO) Concentrations in Plamsa
NO at 4h
|
12.4 umol/L
Standard Error 1.2
|
10.7 umol/L
Standard Error 0.8
|
12.0 umol/L
Standard Error 1.0
|
|
Nitric Oxide (NO) Concentrations in Plamsa
NO at 8h
|
10.5 umol/L
Standard Error 0.6
|
11.4 umol/L
Standard Error 1.3
|
10.0 umol/L
Standard Error 0.8
|
|
Nitric Oxide (NO) Concentrations in Plamsa
NO at 24h
|
10.4 umol/L
Standard Error 0.7
|
10.6 umol/L
Standard Error 0.7
|
10.0 umol/L
Standard Error 0.5
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Interleukin-1alpha (IL-1a) Concentrations in Plasma
IL-1a at 0h
|
17 pg/mL
Standard Error 13
|
21 pg/mL
Standard Error 13
|
68 pg/mL
Standard Error 57
|
|
Interleukin-1alpha (IL-1a) Concentrations in Plasma
IL-1a at 2h
|
49 pg/mL
Standard Error 29
|
54 pg/mL
Standard Error 38
|
61 pg/mL
Standard Error 36
|
|
Interleukin-1alpha (IL-1a) Concentrations in Plasma
IL-1a at 4h
|
30 pg/mL
Standard Error 17
|
70 pg/mL
Standard Error 47
|
66 pg/mL
Standard Error 48
|
|
Interleukin-1alpha (IL-1a) Concentrations in Plasma
IL-1a at 8h
|
43 pg/mL
Standard Error 37
|
40 pg/mL
Standard Error 25
|
75 pg/mL
Standard Error 53
|
|
Interleukin-1alpha (IL-1a) Concentrations in Plasma
IL-1a at 24h
|
33 pg/mL
Standard Error 19
|
52 pg/mL
Standard Error 28
|
73 pg/mL
Standard Error 53
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Interleukin-1beta (IL-1b) Concentrations in Plasma
IL-1b at 0h
|
22 pg/mL
Standard Error 6
|
25 pg/mL
Standard Error 7
|
39 pg/mL
Standard Error 13
|
|
Interleukin-1beta (IL-1b) Concentrations in Plasma
IL-1b at 2h
|
35 pg/mL
Standard Error 8
|
31 pg/mL
Standard Error 9
|
33 pg/mL
Standard Error 4
|
|
Interleukin-1beta (IL-1b) Concentrations in Plasma
IL-1b at 4h
|
26 pg/mL
Standard Error 5
|
32 pg/mL
Standard Error 11
|
39 pg/mL
Standard Error 11
|
|
Interleukin-1beta (IL-1b) Concentrations in Plasma
IL-1b at 8h
|
24 pg/mL
Standard Error 7
|
23 pg/mL
Standard Error 7
|
25 pg/mL
Standard Error 7
|
|
Interleukin-1beta (IL-1b) Concentrations in Plasma
IL-1b at 24h
|
26 pg/mL
Standard Error 6
|
30 pg/mL
Standard Error 10
|
34 pg/mL
Standard Error 12
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Interleukin-2 (IL-2) Concentrations in Plasma
IL-2 at 0h
|
0 pg/mL
Standard Error 0
|
1 pg/mL
Standard Error 1
|
13 pg/mL
Standard Error 11
|
|
Interleukin-2 (IL-2) Concentrations in Plasma
IL-2 at 2h
|
7 pg/mL
Standard Error 7
|
9 pg/mL
Standard Error 9
|
6 pg/mL
Standard Error 3
|
|
Interleukin-2 (IL-2) Concentrations in Plasma
IL-2 at 4h
|
0 pg/mL
Standard Error 0
|
7 pg/mL
Standard Error 6
|
5 pg/mL
Standard Error 3
|
|
Interleukin-2 (IL-2) Concentrations in Plasma
IL-2 at 8h
|
14 pg/mL
Standard Error 13
|
8 pg/mL
Standard Error 7
|
10 pg/mL
Standard Error 8
|
|
Interleukin-2 (IL-2) Concentrations in Plasma
IL-2 at 24h
|
4 pg/mL
Standard Error 2
|
8 pg/mL
Standard Error 6
|
13 pg/mL
Standard Error 11
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Interleukin-4 (IL-4) Concentrations in Plasma
IL-4 at 0h
|
15 pg/mL
Standard Error 4
|
21 pg/mL
Standard Error 8
|
27 pg/mL
Standard Error 8
|
|
Interleukin-4 (IL-4) Concentrations in Plasma
IL-4 at 2h
|
19 pg/mL
Standard Error 6
|
24 pg/mL
Standard Error 7
|
28 pg/mL
Standard Error 8
|
|
Interleukin-4 (IL-4) Concentrations in Plasma
IL-4 at 4h
|
13 pg/mL
Standard Error 5
|
22 pg/mL
Standard Error 8
|
29 pg/mL
Standard Error 7
|
|
Interleukin-4 (IL-4) Concentrations in Plasma
IL-4 at 8h
|
15 pg/mL
Standard Error 7
|
16 pg/mL
Standard Error 5
|
19 pg/mL
Standard Error 6
|
|
Interleukin-4 (IL-4) Concentrations in Plasma
IL-4 at 24h
|
16 pg/mL
Standard Error 5
|
20 pg/mL
Standard Error 6
|
19 pg/mL
Standard Error 7
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Interleukin-6 (IL-6) Concentrations in Plasma
IL-6 at 0h
|
34 pg/mL
Standard Error 13
|
61 pg/mL
Standard Error 36
|
74 pg/mL
Standard Error 29
|
|
Interleukin-6 (IL-6) Concentrations in Plasma
IL-6 at 2h
|
50 pg/mL
Standard Error 22
|
80 pg/mL
Standard Error 34
|
56 pg/mL
Standard Error 23
|
|
Interleukin-6 (IL-6) Concentrations in Plasma
IL-6 at 4h
|
32 pg/mL
Standard Error 14
|
85 pg/mL
Standard Error 51
|
61 pg/mL
Standard Error 24
|
|
Interleukin-6 (IL-6) Concentrations in Plasma
IL-6 at 8h
|
48 pg/mL
Standard Error 24
|
69 pg/mL
Standard Error 31
|
68 pg/mL
Standard Error 29
|
|
Interleukin-6 (IL-6) Concentrations in Plasma
IL-6 at 24h
|
35 pg/mL
Standard Error 13
|
36 pg/mL
Standard Error 16
|
62 pg/mL
Standard Error 26
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Interleukin-8 (IL-8) Concentrations in Plasma
IL-8 at 0h
|
7 pg/mL
Standard Error 2
|
12 pg/mL
Standard Error 4
|
19 pg/mL
Standard Error 7
|
|
Interleukin-8 (IL-8) Concentrations in Plasma
IL-8 at 2h
|
11 pg/mL
Standard Error 4
|
12 pg/mL
Standard Error 4
|
24 pg/mL
Standard Error 11
|
|
Interleukin-8 (IL-8) Concentrations in Plasma
IL-8 at 4h
|
8 pg/mL
Standard Error 3
|
12 pg/mL
Standard Error 4
|
18 pg/mL
Standard Error 6
|
|
Interleukin-8 (IL-8) Concentrations in Plasma
IL-8 at 8h
|
11 pg/mL
Standard Error 4
|
9 pg/mL
Standard Error 2
|
16 pg/mL
Standard Error 6
|
|
Interleukin-8 (IL-8) Concentrations in Plasma
IL-8 at 24h
|
11 pg/mL
Standard Error 4
|
12 pg/mL
Standard Error 4
|
19 pg/mL
Standard Error 8
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Interleukin-10 (IL-10) Concentrations in Plasma
IL-10 at 0h
|
21 pg/mL
Standard Error 5
|
18 pg/mL
Standard Error 5
|
19 pg/mL
Standard Error 4
|
|
Interleukin-10 (IL-10) Concentrations in Plasma
IL-10 at 2h
|
15 pg/mL
Standard Error 3
|
14 pg/mL
Standard Error 4
|
14 pg/mL
Standard Error 3
|
|
Interleukin-10 (IL-10) Concentrations in Plasma
IL-10 at 4h
|
14 pg/mL
Standard Error 3
|
12 pg/mL
Standard Error 4
|
14 pg/mL
Standard Error 4
|
|
Interleukin-10 (IL-10) Concentrations in Plasma
IL-10 at 8h
|
14 pg/mL
Standard Error 3
|
13 pg/mL
Standard Error 4
|
17 pg/mL
Standard Error 3
|
|
Interleukin-10 (IL-10) Concentrations in Plasma
IL-10 at 24h
|
15 pg/mL
Standard Error 4
|
12 pg/mL
Standard Error 4
|
14 pg/mL
Standard Error 3
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Interferon-gamma (IFN-y) Concentrations in Plasma
IFN-y at 0h
|
13 pg/mL
Standard Error 7
|
20 pg/mL
Standard Error 10
|
16 pg/mL
Standard Error 10
|
|
Interferon-gamma (IFN-y) Concentrations in Plasma
IFN-y at 2h
|
11 pg/mL
Standard Error 6
|
17 pg/mL
Standard Error 8
|
16 pg/mL
Standard Error 9
|
|
Interferon-gamma (IFN-y) Concentrations in Plasma
IFN-y at 4h
|
14 pg/mL
Standard Error 8
|
16 pg/mL
Standard Error 9
|
16 pg/mL
Standard Error 9
|
|
Interferon-gamma (IFN-y) Concentrations in Plasma
IFN-y at 8h
|
8 pg/mL
Standard Error 6
|
14 pg/mL
Standard Error 8
|
15 pg/mL
Standard Error 8
|
|
Interferon-gamma (IFN-y) Concentrations in Plasma
IFN-y at 24h
|
9 pg/mL
Standard Error 6
|
10 pg/mL
Standard Error 6
|
13 pg/mL
Standard Error 8
|
PRIMARY outcome
Timeframe: 0, 2, 4, 8, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Tumor Necrosis Factor-alpha (TNF-a) Concentrations in Plasma
TNF-a at 0h
|
23 pg/mL
Standard Error 6
|
34 pg/mL
Standard Error 11
|
30 pg/mL
Standard Error 9
|
|
Tumor Necrosis Factor-alpha (TNF-a) Concentrations in Plasma
TNF-a at 2h
|
24 pg/mL
Standard Error 6
|
21 pg/mL
Standard Error 7
|
31 pg/mL
Standard Error 8
|
|
Tumor Necrosis Factor-alpha (TNF-a) Concentrations in Plasma
TNF-a at 4h
|
20 pg/mL
Standard Error 6
|
36 pg/mL
Standard Error 16
|
41 pg/mL
Standard Error 12
|
|
Tumor Necrosis Factor-alpha (TNF-a) Concentrations in Plasma
TNF-a at 8h
|
18 pg/mL
Standard Error 6
|
22 pg/mL
Standard Error 7
|
27 pg/mL
Standard Error 11
|
|
Tumor Necrosis Factor-alpha (TNF-a) Concentrations in Plasma
TNF-a at 24h
|
19 pg/mL
Standard Error 7
|
20 pg/mL
Standard Error 7
|
26 pg/mL
Standard Error 14
|
PRIMARY outcome
Timeframe: 0, 3, 6, 9, 12, 24 hOutcome measures
| Measure |
Low Calorie Cranberry Juice Cocktail
n=12 Participants
Beverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Low Calorie Cranberry Juice Cocktail: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Cranberry Leaf Extract Beverage
n=12 Participants
Beverage containing cranberry leaf extract: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Leaf Extract Beverage: Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
Non-Cranberry Beverage
n=12 Participants
Beverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage: Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
|
|---|---|---|---|
|
Urinary Anti-bacteria Adhesion Activity
0h
|
0.39 mg PAC/mg creatinine
Standard Error 0.14
|
0.45 mg PAC/mg creatinine
Standard Error 0.11
|
0.30 mg PAC/mg creatinine
Standard Error 0.05
|
|
Urinary Anti-bacteria Adhesion Activity
3h
|
2.34 mg PAC/mg creatinine
Standard Error 0.73
|
2.54 mg PAC/mg creatinine
Standard Error 0.61
|
1.62 mg PAC/mg creatinine
Standard Error 0.32
|
|
Urinary Anti-bacteria Adhesion Activity
6h
|
0.97 mg PAC/mg creatinine
Standard Error 0.26
|
1.05 mg PAC/mg creatinine
Standard Error 0.29
|
1.14 mg PAC/mg creatinine
Standard Error 0.37
|
|
Urinary Anti-bacteria Adhesion Activity
9h
|
0.66 mg PAC/mg creatinine
Standard Error 0.14
|
0.76 mg PAC/mg creatinine
Standard Error 0.16
|
0.59 mg PAC/mg creatinine
Standard Error 0.15
|
|
Urinary Anti-bacteria Adhesion Activity
12h
|
0.50 mg PAC/mg creatinine
Standard Error 0.07
|
0.56 mg PAC/mg creatinine
Standard Error 0.08
|
0.67 mg PAC/mg creatinine
Standard Error 0.13
|
|
Urinary Anti-bacteria Adhesion Activity
24h
|
0.38 mg PAC/mg creatinine
Standard Error 0.06
|
0.48 mg PAC/mg creatinine
Standard Error 0.07
|
0.54 mg PAC/mg creatinine
Standard Error 0.10
|
Adverse Events
Low Calorie Cranberry Juice Cocktail
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Cranberry Leaf Extract Beverage
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Non-Cranberry Beverage
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place