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Orange Juice Consumption and Cognitive Function

NCT ID: NCT01312610

Last Updated: 2011-11-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-09-30

Study Completion Date

2011-09-30

Brief Summary

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This study is investigating the effect of 8 weeks of orange juice supplementation on executive function in healthy older adults. The study is a controled, double-blind, crossover trial and involves a 8 week supplementation with a high flavonone orange juice and a carbohydrate-matched control. Volunteers consume 500ml of either the test juice or the control juice per day for an 8 week period. There is then an 8 week washout period before subjects proceed to the other arm of the study. Subjects are randomly assigned to either arm at the beginning of the study. Measures of cognitive function will be administered pre and post both test and control interventions. Blood pressure will also be measured and blood and urine samples will be collected to assess absorption of from the juice. A sub-sample of volunteers will undergo MRI imaging pre- and post intervention to acquire cerebral blow flow information.

Detailed Description

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Conditions

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Nerve Degeneration

Keywords

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orange juice cognitive function flavonoids flavanones

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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High flavonone orange juice drink

Group Type EXPERIMENTAL

High flavanone orange juice

Intervention Type DIETARY_SUPPLEMENT

High flavonone orange juice drink.

Control orange juice drink

Juice drink matched for sugar content

Group Type PLACEBO_COMPARATOR

Control orange juice

Intervention Type DIETARY_SUPPLEMENT

Orange beverage, low flavanone content, matched for total carbohydrate content, individual sugar profile, vitamin C

Interventions

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High flavanone orange juice

High flavonone orange juice drink.

Intervention Type DIETARY_SUPPLEMENT

Control orange juice

Orange beverage, low flavanone content, matched for total carbohydrate content, individual sugar profile, vitamin C

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Frozen Orange Juice; Department of Citrus, Florida, USA.

Eligibility Criteria

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Inclusion Criteria

* In good general health i.e. no major health condition such as diabetes
* BMI \< 30
* Cholesterol \< 6 and BP \< 150/90
* Not on blood pressure medication or blood thinning medication such as aspirin - No learning difficulty such as dyslexia

Exclusion Criteria

* Diabetes
* Gastro-intestinal disease
* High BMI
* Cholesterol and BP
* Smoker
* On blood pressure medication or blood thinning medication such as aspirin
* Dyslexic/dyspraxic
* Depression or history of depression
Minimum Eligible Age

60 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Reading

OTHER

Sponsor Role lead

Responsible Party

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Jeremy Paul Edward Spencer

Professor Jeremy Spencer

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jeremy PE Spencer, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Reading

Laurie T. Butler, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Reading

Locations

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University of Reading

Reading, Berkshire, United Kingdom

Site Status

Countries

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United Kingdom

References

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Kean RJ, Lamport DJ, Dodd GF, Freeman JE, Williams CM, Ellis JA, Butler LT, Spencer JP. Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults. Am J Clin Nutr. 2015 Mar;101(3):506-14. doi: 10.3945/ajcn.114.088518. Epub 2015 Jan 14.

Reference Type DERIVED
PMID: 25733635 (View on PubMed)

Other Identifiers

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UReading_2010_OJOC

Identifier Type: -

Identifier Source: org_study_id