Sirtuin Mediated Effects of 36 Hour Fast and 1 Hour Exercise

NCT ID: NCT00978640

Last Updated: 2012-06-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-09-30

Study Completion Date

2012-06-30

Brief Summary

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Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).

Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.

In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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fasting and exercise

36 h fast and 1 h ergometer cycling 50% VO2max

Group Type EXPERIMENTAL

fast and exercise

Intervention Type OTHER

fasting 36 h and exercise 1 h 50% VO2max

exercise

1 h ergometer cycling 50% VO2max

Group Type EXPERIMENTAL

exercise

Intervention Type OTHER

exercise 1 h 50% VO2max

Interventions

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fast and exercise

fasting 36 h and exercise 1 h 50% VO2max

Intervention Type OTHER

exercise

exercise 1 h 50% VO2max

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* healthy men
* Body mass index (BMI) 20-26
* age 18-45 years

Exclusion Criteria

* any kind of disease
* any use of medicine
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Aarhus

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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mikkel Holm Vendelbo

Aarhus, Jylland, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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07.09.2009

Identifier Type: -

Identifier Source: org_study_id

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