Role of Fasted Exercise on Improving Cardiometabolic Health
NCT ID: NCT05742373
Last Updated: 2024-03-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
30 participants
INTERVENTIONAL
2023-03-01
2025-05-31
Brief Summary
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Detailed Description
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The objectives are to investigate:
1. The effect of a single bout of fasted exercise on acute metabolic responses following a high fat meal.
2. The effect of four weeks of fasted exercise training on cardiovascular and metabolic disease risk factors.
3. The effect of four weeks of fasted exercise training on circulating levels and subcutaneous adipose tissue gene expression of SIRT1, SIRT3 and SIRT6.
A randomised control trial will be conducted with volunteers allocated under the conditions of a) no exercise (control), b) fasted exercise training (FASTEX) and c) fed exercise training (FEDEX). The pre- and post-intervention visits will consist of 50 minutes of cycling at a moderate exercise intensity for both the FASTEX and FEDEX groups. The control group would not perform any exercise. The FASTEX group will perform the exercise in the fasted state, whilst the FEDEX and control groups will be fed a standardised breakfast meal one hour in advance of the exercise period. Following the exercise period, the participants will be fed a high fat meal and metabolic responses to the meal will be measured for four hours. Multiple blood samples will be obtained as well as a sample of subcutaneous adipose (fat) tissue. The FASTEX and FEDEX groups will then complete four weeks of moderate intensity continuous exercise training, either fasted or fed according to their group, on three days per week whilst the control group will maintain their normal sedentary lifestyle. All participants will return to the laboratory for post-intervention testing at the end of the four weeks with the same protocols and measurements as the pre-intervention testing.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Fasted exercise
Exercise training in the fasted state
Exercise training in the fasted state
Four weeks of moderate intensity cycling exercise, three times a week without eating breakfast meal
Fed exercise
Exercise training in the fed state
Exercise training in the fed state
Four weeks of moderate intensity cycling exercise, three times a week, after eating breakfast meal
Control
No exercise training
No interventions assigned to this group
Interventions
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Exercise training in the fasted state
Four weeks of moderate intensity cycling exercise, three times a week without eating breakfast meal
Exercise training in the fed state
Four weeks of moderate intensity cycling exercise, three times a week, after eating breakfast meal
Eligibility Criteria
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Inclusion Criteria
* Non-smokers
* Physically inactive (partake in no more than one exercise session per week on average)
* Body mass index \>18.5 kg/m2
* Healthy as assessed by medical screening questionnaire
* Prior recipient of local anaesthetic with no known adverse effects, no known hypersensitivity or no other health issue that may constrain the administration of lidocaine hydrochloride
* Free from musculoskeletal injury and able to perform cycling exercise
* Capacity to give informed consent
Exclusion Criteria
* BMI \< 18.5 kg/m2
* Pregnant
* Allergy or intolerances to test meal products/ingredients (such as wheat or dairy products).
* Recent major body weight change (+/- 3 kg in the past month)
* Known hypersensitivity to Lidocaine Hydrochloride
* Cardiovascular disease - complete heart block or hypovolaemia
* Adam's-Stokes Syndrome
* Wolff-Parkinson-White Syndrome
* Porphyria
* Epilepsy
* Myasthenia Gravis
* Other chronic medical condition or diagnosis including respiratory (eg asthma), endocrine, cardiovascular, neuromuscular disorders.
* Taking medications or receiving treatment that may constrain the administration of lidocaine or local anaesthesia.
18 Years
40 Years
ALL
Yes
Sponsors
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European Society for Clinical Nutrition and Metabolism
OTHER
Manchester Metropolitan University
OTHER
Responsible Party
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Adora Yau
Senior Lecturer
Principal Investigators
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Adora Yau, PhD
Role: PRINCIPAL_INVESTIGATOR
Manchester Metropolitan University
Gethin Evans, PhD
Role: STUDY_DIRECTOR
Manchester Metropolitan University
Locations
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Manchester Metropolitan University
Manchester, Greater Manchester, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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FastExTrainESPEN2022
Identifier Type: -
Identifier Source: org_study_id
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