Oxidative Stress as an Acute Exercise-induced Mechanism of Stem and Progenitor Cell Mobilization
NCT ID: NCT03747913
Last Updated: 2019-12-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2019-05-02
2019-10-31
Brief Summary
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The investigators hypothesize that exercise-induced oxidative stress could be at least one of the responsible mechanisms and therefore want to study the exercise-induced stem and progenitor cell mobilization in a group of healthy young men when they exercise with, compared to when they exercise without antioxidative supplementation.
The primary outcome is numbers of stem and progenitor cells in the peripheral blood after an acute bout of exercise. As a secondary outcome, numbers of apoptotic mature and immature cells in the blood will be analysed.
Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Antioxidative Supplementation
Each participant conducts two identical cycling tests, first without and a week later with antioxidative supplementation
Antioxidative supplementation
Each participant conducts two identical cycling tests, first without and a week later with antioxidative supplementation
Interventions
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Antioxidative supplementation
Each participant conducts two identical cycling tests, first without and a week later with antioxidative supplementation
Eligibility Criteria
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Inclusion Criteria
* Healthy
* Normal Body-Mass-Index (BMI): 18.5-24.9 kg∙m-2
* Active (fulfill World Health Organization-guidelines for recommended levels of physical activity for adults aged 18 - 64 years)
* Willing to adhere to the study rules
Exclusion Criteria
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders etc. of the participant
* Previous enrolment into the current study
* Enrolment of the investigator, his/her family members, employees and other dependent persons
* Regular intake of medication
* Regular intake of antioxidant supplementations
18 Years
35 Years
MALE
Yes
Sponsors
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Swiss Federal Institute of Technology
OTHER
Responsible Party
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Locations
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Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich
Zurich, Canton of Zurich, Switzerland
Countries
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References
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Schmid M, Martins HC, Schratt G, Kropfl JM, Spengler CM. MiRNA126 - RGS16 - CXCL12 Cascade as a Potential Mechanism of Acute Exercise-Induced Precursor Cell Mobilization. Front Physiol. 2021 Dec 9;12:780666. doi: 10.3389/fphys.2021.780666. eCollection 2021.
Other Identifiers
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EISMO
Identifier Type: -
Identifier Source: org_study_id