FAXAGE: Fasting And Exercise To Slow Aging In Humans

NCT ID: NCT07207044

Last Updated: 2026-01-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

240 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-10-01

Study Completion Date

2042-08-30

Brief Summary

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FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise and fasting group and a control group. The intervention will last for one year, and tests of biomarkers of aging will be performed at baseline, after 3 months, 6 months and at the end of the intervention. A reference group of participants over the age of 20 equally distributed by age and sex will be used to train an algorithm for determination of biological age. The study will include both physical, molecular and digital biomarkers including DNA-methylation, VO2max, body composition and face- and voice-age. The main outcome of the project is DNA-methylation age at week 52. Secondary outcomes are the rest of the tested biomarkers at week 52. It is hypothesised that the intervention groups will have similar superior benefits after the 52 weeks of intervention.

Detailed Description

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Conditions

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Aging Healthy Aging Aging Frailty

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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TRF

Group Type EXPERIMENTAL

Time-restricted feeding

Intervention Type BEHAVIORAL

Time-restricted feeding in a 16/8 regimen - 16 hours of fast and 8 hours of eating per day.

EXE

Group Type EXPERIMENTAL

Exercise - Strength + Cardio

Intervention Type BEHAVIORAL

Supervised strength training 2x/week + self-administered cardio training 2x/week.

FAX

Group Type EXPERIMENTAL

Time-restricted feeding + Exercise

Intervention Type BEHAVIORAL

Strength and cardio exercise 2x/week each combined with time-restricted feeding in a 16/8 regimen.

CON

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise - Strength + Cardio

Supervised strength training 2x/week + self-administered cardio training 2x/week.

Intervention Type BEHAVIORAL

Time-restricted feeding

Time-restricted feeding in a 16/8 regimen - 16 hours of fast and 8 hours of eating per day.

Intervention Type BEHAVIORAL

Time-restricted feeding + Exercise

Strength and cardio exercise 2x/week each combined with time-restricted feeding in a 16/8 regimen.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Provision of signed and dated informed consent
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Aged \>20 years
* In good general health meaning maximally 1 well-managed chronic disease
* Non-smoker.

Exclusion Criteria

* Inability or unwillingness to adhere to the TRF regiment
* Inability or unwillingness to perform the prescribed physical exercise
* Treatment with other investigational drug or intervention within 1 year
* \>1 hour of systematic strenuous exercise or strength training a week
* Current time-restricted eating habits
* Severe or dysregulated medical disease (i.e. active cancer, uncontrolled diabetes, severe pulmonary or heart disease)
* \>1 well-managed chronic disease
* Smoker
* Use of systemic glucocorticoids, androgens or antiandrogens.
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Copenhagen

Copenhagen, Copenhagen N, Denmark

Site Status RECRUITING

Countries

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Denmark

Facility Contacts

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Morten Scheibye-Knudsen, MD

Role: primary

+4542507060

Other Identifiers

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H-25020642

Identifier Type: -

Identifier Source: org_study_id

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