Targeting Aging and Promoting Longevity with Exogenous Nucleotides (TALENTs)

NCT ID: NCT05243108

Last Updated: 2025-01-29

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 122 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-08-23
• Study Completion Date: 2023-03-29

Brief Summary

To investigate the effects of dietary nucleotides (NTs) as an anti-aging supplement, a clinical trial is carried as a randomized, double-blind, parallel design, placebo-controlled. A total of 120 subjects will be enrolled in the study, and they shall be randomly distributed between the two arms, NTs-treated, and placebo-control. They would be given several measurements, including physical examination, questionnaire survey, clinical and aging-related biomarkers tests at 0 (baseline), 2, and 4 months during the RCT.

Detailed Description

To explore the anti-aging effects of NTs and the regulation of aging-related diseases, this study plans to recruit 120 people as subjects and conduct randomized controlled trials with NTs as an intervention for 4 months. Based on computer-generated random numbers, participants who meet the inclusion criteria are randomly assigned equally to two groups: placebo control and nucleotide intervention groups. In this study, the specific nucleotide composition is 5'-AMP、5'-CMP、5'-GMPNa2、5'-UMPNa2 prepared according to the ratio of 16:41:19:24, which is consistent with the ratio in breast milk and meets the requirements of national infant formula addition and special medical food formula. The dose of 1.2 g/day used is currently approved as the ingredient dose of nucleotides in conventional commercially available health food products. At the 0、2 and 4 months of the study, comprehensive geriatric health assessment, aging biomarker testing and biological sample collection will be conducted. Among them, the comprehensive evaluation of elderly health status is carried out by physical examination and questionnaire survey, including physical health, physiological function, quality of life, cognitive function, psychosocial health, and other aspects of information. The physical examination involves both physical assessment and functional assessment, including body composition, neck circumference, waist circumference, hip circumference, middle arm circumference, calf circumference, BMR, grip strength, six-minute walk, intima-media thickness, subcutaneous AGEs, and spirometry. The scale includes health status, nutritional status, cognitive status, physical activity, and dietary status. Blood samples were used to detect the safety and senescence-related indicators of the subjects. The index system covers four modules and seventeen dimensions, including blood routine, blood biochemistry, inflammatory factors, immune antibodies, T lymphocyte subtypes, oxidative stress level, cancer markers, leukocyte telomere length, DNA methylation, γ-H2A. Blood samples are sequenced simultaneously for gene and transcriptome sequencing. Fecal samples are collected for metagenomic sequencing of intestinal flora.

Conditions

Aging

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: QUADRUPLE

Study Groups

NTs Intervention group

The subject of 1200mg has been given orally once a day for 4 months.

Group Type: EXPERIMENTAL

dietary nucleotides

Intervention Type: DIETARY_SUPPLEMENT

1.2 g/d NTs (5 '-AMP, 5' -CMP, 5 '-GMPNa2, 5' -UMPNa2) ;

placebo control group

The ingredients, dosage, and usage are the same as experimental.

Group Type: PLACEBO_COMPARATOR

placebo

Intervention Type: DIETARY_SUPPLEMENT

placebo

Interventions

dietary nucleotides

1.2 g/d NTs (5 '-AMP, 5' -CMP, 5 '-GMPNa2, 5' -UMPNa2) ;

Intervention Type: DIETARY_SUPPLEMENT

placebo

placebo

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

1. Male/females of 60 to 70 years of age

2. No serious physical or mental illness

3. Able to provide written Informed Consent

4. Able to follow verbal and written study directions

5. Must not be taking or be willing to take any supplements containing any form of nucleotides for one year prior to baseline and for the duration of the study.

6. Able to maintain consistent diet and lifestyle habits throughout the study

7. Willing to consume assigned supplement (NTs or placebo) for 4 months

Exclusion Criteria

1. Participants on the current use of prescription or over-the-counter nucleotides

2. Having abnormal screening laboratory test values or other lab test result(s) that would preclude study participation in the judgment of the investigator

3. Documented presence of atherosclerotic disease and/or cardiopulmonary disease

4. History of drug or alcohol abuse

5. History of unstable depression or mental illness within the last 6 months for which the investigator believes could impact the participant's ability to comply with study requirements

6. Other diseases or medications, according to the investigator, that would interfere directly in the results of the study or jeopardize the health of the participant.

7. Currently, or within the past 30 days, enrolled in a different clinical investigation

8. Inability to provide a venous blood sample

9. Unable or unwilling to provide written informed consent for participation in the study

• Minimum Eligible Age: 60 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Peking University

OTHER

Sponsor Role: lead

Responsible Party

Meihong Xu

Associate professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Meihong Xu, Assis prof.

Role: PRINCIPAL_INVESTIGATOR

Peking University

Locations

Talents project team

Chengdu, Sichuan, China

Countries

China

References

Wang S, Song L, Fan R, Chen Q, Fu R, You M, Wu Y, Cai M, Li Y, Xu M. Nucleotides as an Anti-Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study). Adv Sci (Weinh). 2025 Sep;12(33):e2417728. doi: 10.1002/advs.202417728. Epub 2025 May 28.

Reference Type: DERIVED

PMID: 40433895 (View on PubMed)

Other Identifiers

TALENTs

Identifier Type: -

Identifier Source: org_study_id