Impact of Health Education on Knowledge, Attitude and Practice of Post-exposure Prophylaxis

NCT ID: NCT07330427

Last Updated: 2026-01-09

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 340 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-06-01
• Study Completion Date: 2026-02-01

Brief Summary

Occupational exposure to blood-borne pathogens, such as human immune-deficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) for healthcare workers through contact with human blood and body fluids has become a major health concern as it poses a risk of transmission of these infectious agents.

According to the World Health Organization (WHO) report, about three million HCWs are exposed to blood-borne pathogens each year, of which 170,000 are exposed to HIV infections, 2 million to HBV infections, and 0.9 million to HCV infections. Most of the time, healthcare providers get exposure through the splash of blood or other body fluids into the eyes, nose, or mouth or nonintact skin exposure, and percutaneous injury occurs as a result of a break in the skin caused by a needlestick or sharps contaminated with blood or body fluids

Detailed Description

Post exposure prophylaxis is defined by the World Health Organization (WHO) as the medical intervention offered to prevent the transmission of blood-borne diseases following a potential exposure to HIV, HBV, HCV, and other viruses.

In developing regions, 40%-65% of HBV and HCV infections in health care workers are attributable to percutaneous occupational exposure .Approximately 3 out of 35 million HCWs worldwide experience needlestick injuries (NSIs) annually, exposing them to blood-borne pathogens .

In Egypt, like many developing countries, few efforts have been undertaken to raise awareness about needlestick injury (NSI) among HCWs . There is a lack of regulations and policies to protect HCWs from exposure. HCWs rarely receive training in infection control and standard precautions, even though these are low-cost solutions to reducing the risk of sharp injuries and have a high likelihood of being adopted .

There is a lack of data and surveillance concerning health care-related occupational exposures and the use of PEP. Furthermore, unsafe practices are frequently observed, placing patients and healthcare workers at risk of infection.

knowledge and practice of PEP for HIV/HBV. As a result, the study recommended the establishment of PEP training centre with proper guidelines in order to enhance the utilization of PEP.

No empirical data exists on the knowledge and attitudes of HCWs toward post exposure prophylaxis following occupational exposure to the blood-borne viruses at Aswan University Hospital. Hence the study will apply interventions in the form of an education module designed to suit the need of each of these categories of HCWs (doctors, nurses, and ward aides). Furthermore, the study seeks to implement and evaluate the effectiveness of an education program regarding post exposure prophylaxis on their change in knowledge, attitude, and practice.

Conditions

Post Exposure Prophylaxis

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: NONE

Study Groups

Health Care workers

About 340 participants of heath care workers undergoing assessment of knowledge, attitude and practice about post-exposure prophylaxis among health care workers at Aswan university hospital, Egypt Then they will undergo lecturers about about post-exposure prophylaxis, then reassessment will be done after 3 months

Group Type: EXPERIMENTAL

Health Education

Intervention Type: PROCEDURE

1. Assess the baseline knowledge, attitudes and practices of health care workers at Aswan university hospital towards postexposure prophylaxis against blood-borne viral infection.

2. Provide an intense post exposure prophylaxis health education sessions.

3. Evaluate changes in post exposure prophylaxis knowledge, attitudes and practices after the health education intervention.

Interventions

Health Education

1. Assess the baseline knowledge, attitudes and practices of health care workers at Aswan university hospital towards postexposure prophylaxis against blood-borne viral infection.

2. Provide an intense post exposure prophylaxis health education sessions.

3. Evaluate changes in post exposure prophylaxis knowledge, attitudes and practices after the health education intervention.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. HCWs at the selected departments (physicians, nurses and housekeepers).

2. Age >18 years old and below 60 years old in both Genders.

3. HCWs which have direct contact with blood and body fluids.

Exclusion Criteria

1. Age<18 years old and above 60 years old.

2. Non-medical staff at Aswan university hospital.

3. Health care workers which have no contact with blood or body fluids.

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Aswan University

OTHER

Sponsor Role: lead

Responsible Party

Fatma Ali Mahmoud Hussein

Demonstrator at Public Health and Community Medicine, Faculty of medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Shaimaa Sayed Abdelrheem, M.D

Role: STUDY_CHAIR

Associate Professor of Public Health and Community Medicine, Faculty of medicine, Aswan University

Locations

Aswan faculty of Medicine

Aswān, , Egypt

Site Status: RECRUITING

Countries

Egypt

Central Contacts

Fatma Ali Mahmoud Hussein, MSc

Role: CONTACT

fatma.mahmoud@med.aswu.edu.eg

+201153368599

Shaimaa Sayed Abdelrheem, Professor

Role: CONTACT

dr_shimaasayed@yahoo.com

+201064031040

Facility Contacts

Shimaa Abdalaleem Abdalgeleel, Professor

Role: primary

+201092811522

Mohamed Mostafa Amin Ali, Professor

Role: backup

mohamed.mostafa@aswu.edu.eg

+201092811522

Other Identifiers

Post-exposure prophylaxis

Identifier Type: -

Identifier Source: org_study_id