Evaluation of the Variation of the Sub-pulmonary Velocity-time Integral to Predict Fluid Responsiveness

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

205 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-11-07

Study Completion Date

2027-05-31

Brief Summary

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Fluid administration is the first-line treatment in hypovolemic states in critically ill patients. Prediction of fluid responsiveness is possible with echocardiography by assessing the variation of the sub-aortic velocity-time integral (AoVTI) during a passive leg raising test (PLR) or Mini-fluid challenge. However, VTI-Ao measurement is not feasible in all patients due to poor echogenicity. Validation of new fluid-responsiveness indices may facilitate the evaluation in this patient population. Among the available indices, variation of the sub-pulmonary VTI is a potential criterion.

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Detailed Description

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Conditions

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Fluid Resuscitation Fluid Responsiveness Predictability

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients suspected of hypovolemia

Patients with suspected hypovolemia who need to be evaluated for fluid responsiveness

Fluid bolus administration

Intervention Type DRUG

Fluid infusion of 500 mL of a crystalloïd solution is performed for patients with signs of hypovolemia

Interventions

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Fluid bolus administration

Fluid infusion of 500 mL of a crystalloïd solution is performed for patients with signs of hypovolemia

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patient with measurable sub-pulmonary VTI in at least one of the two windows: parasternal short-axis or subcostal.
* Patient with measurable sub-aortic VTI in apical 4-chamber view before and after PLR maneuver.
* Patient with suspected hypovolemia or whose hemodynamic status justifies vasopressor infusion.

Exclusion Criteria

* Severe left ventricular dysfunction defined by left ventricular ejection fraction (LVEF) \< 30%.
* Severe right ventricular dysfunction defined by TAPSE \< 12 mm.
* Cardiac arrhythmia or atrial fibrillation.
* Abdominal compartment syndrome.
* Amputation of one or both lower limbs.
* Intracranial hypertension.
* Pregnant women (ruled out by systematic pregnancy test at ICU admission).
* Minors.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No