Relation Between the Increase of Peripheral Edema by Fluid Therapy and the Decrease in Microcirculatory Vesseldensity
NCT ID: NCT02661269
Last Updated: 2018-03-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
110 participants
OBSERVATIONAL
2015-11-01
2018-02-15
Brief Summary
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Primary outcome:
\- Total vessel density (TVD)
Secondary outcome:
* Fluid balance
* BIVA measurements (reactance \& resistance)
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Detailed Description
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With sublingual measurements of the vessel density with the Cytocam-IDF, comparing the septic patients with fluid overload , euvolemic post-cardiac surgery patients at the arrival on the ICU and healthy volunteers we can determine if there is a decrease in vessel density during fluid loading.
To give a accurate view on fluid overload we include a bio-impedance measurement of reactance and resistance. Fluid balances are recorded very accurate by our electronic patient record.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Septic patients
Septic patients with fluid overload (fluid balance + 4 L)
Videomicroscopy of the sublingual microcirculation
Measuring total vessel density with the Cytocam-IDF camera.
Bio-impedance measurements.
measuring resistance and reactance with the BIVA method.
Post-cardiac surgery patients
Patients after cardiac surgery, at arrival on ICU.
Videomicroscopy of the sublingual microcirculation
Measuring total vessel density with the Cytocam-IDF camera.
Bio-impedance measurements.
measuring resistance and reactance with the BIVA method.
Interventions
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Videomicroscopy of the sublingual microcirculation
Measuring total vessel density with the Cytocam-IDF camera.
Bio-impedance measurements.
measuring resistance and reactance with the BIVA method.
Eligibility Criteria
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Inclusion Criteria
* septic patient with a fluid balance of 4L +
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Frisius Medisch Centrum
OTHER
Responsible Party
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Gerke Veenstra
MD
Principal Investigators
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E.C. Boerma, MD-PhD
Role: PRINCIPAL_INVESTIGATOR
Frisius Medisch Centrum
Locations
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Medical Centre Leeuwarden
Leeuwarden, Provincie Friesland, Netherlands
Countries
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Other Identifiers
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nWMO 127
Identifier Type: -
Identifier Source: org_study_id
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