Comparison of 5% Nacl and 10% NaHCO3 As Contrast Agents for Lung Perfusion with EIT

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-04-01

Study Completion Date

2024-08-26

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Electrical impedance tomography (EIT) has enabled the bedside monitoring of lung perfusion measurement through the indicator-based contrast method. Currently, hypertonic sodium chloride is the most commonly used contrast agent for lung perfusion evaluation by EIT. However, concerns may be raised regarding the potential risks of hyperchloremia and possible acute kidney injury associated with the use of hypertonic NaCl. Recently, two experimental studies found sodium bicarbonate (NaHCO3) might be an alternative to hypertonic sodium chloride in lung perfusion assessment by EIT. However, whether NaHCO3 results in acceptable bias is unknown in critically ill patients. This clinical study aimed to further investigate the correlation and agreement of lung perfusion and Ventilation/perfusion (V/Q) match by EIT contrast method between two contrast indicators (5%NaHCO3 vs. 10% NaCl) in critically ill patients with respiratory failure.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Low-chlorine Vs High-chlorine Crystalloids in Septic Shock Adults

NCT04365010

Septic Shock

UNKNOWN PHASE4

Resuscitation Fluid Choice and Clinical Outcomes

NCT02641119

Large Volume Resuscitation Acute Kidney Injury Hyperchloremic Metabolic Acidosis

COMPLETED

Optimization of Fluid Balance Guided by Bioelectrical Impedance Analysis in Patients Undergoing Continuous Renal Replacement Therapy in Critical Care

NCT06799910

Congestion RRT UF +4 more

RECRUITING NA

Bio Electrical Impedance Analysis to Monitor Fluid Status During Deresuscitation Strategy in Continuous Renal Replacement Therapy

NCT05160467

Fluid Overload

UNKNOWN

Assessment of Hydration Status Using Bioelectrical Impedance Vector Analysis

NCT02936440

Acute Kidney Injury Critical Illness

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

ARDS (Acute Respiratory Distress Syndrome)

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

NaCl

First, perform the EIT contrast method with 10% NaCl. After a 10-minute washout period, perform the EIT contrast method with 5% NaHCO3.

Group Type EXPERIMENTAL

Injection of hypertonic saline

Intervention Type OTHER

Injection 10 mL of 10% NaCl through central venous catheter

Injection of 5% NaHCO3

Intervention Type OTHER

Injection of 5% NaHCO3 through central venous catheter

NaHCO3

First, perform the EIT contrast method with 5% NaHCO3. After a 10-minute washout period, perform the EIT contrast method with 10% NaCl.

Group Type OTHER

Injection of hypertonic saline

Intervention Type OTHER

Injection 10 mL of 10% NaCl through central venous catheter

Injection of 5% NaHCO3

Intervention Type OTHER

Injection of 5% NaHCO3 through central venous catheter

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Injection of hypertonic saline

Injection 10 mL of 10% NaCl through central venous catheter

Intervention Type OTHER

Injection of 5% NaHCO3

Injection of 5% NaHCO3 through central venous catheter

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* In need of lung perfusion assessment due to clinical condition
* With central venous catheter

Exclusion Criteria

* contraindications to the use of EIT (automatic implantable cardioverter defibrillator, chest wounds limiting electrode belt placement, implantable pumps, etc.)
* severe hyperchloremia (\>155 mmol/L)
* unable to tolerate breath-hold maneuver
* pregnant or breastfeeding females

Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No