Comparing Mirror Therapy and CIMT for Hand and Arm Function in Post-Stroke Patients

NCT ID: NCT07139015

Last Updated: 2025-08-24

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 42 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-10-08
• Study Completion Date: 2026-01-02

Brief Summary

The goal of this clinical trial is to find out whether Mirror Therapy (MT) combined with Constraint-Induced Movement Therapy (CIMT) improves hand and arm function after a stroke. The study will also compare this combination to CIMT alone. The main questions it aims to answer are:

Does combining MT with CIMT improve grip strength, hand dexterity, and upper limb function more than CIMT alone? Which therapy is more effective in helping stroke survivors regain use of their arm and hand?

Participants will:

Be randomly assigned to receive either CIMT alone or CIMT combined with MT Attend therapy sessions 5 days a week for 6 weeks, each lasting 60-90 minutes Undergo tests before and after treatment to measure grip strength, dexterity, and motor function using tools like the Fugl-Meyer Assessment, Box and Block Test, and Hand-Held Dynamometer

Detailed Description

This randomized clinical trial aims to evaluate and compare the effects of Mirror Therapy (MT) and Constraint-Induced Movement Therapy (CIMT) on grip strength, hand dexterity, and upper limb motor function in post-stroke patients. Stroke is a leading cause of long-term disability, particularly affecting upper limb motor function, which severely impacts the ability to perform daily activities. This study seeks to provide insights into which approach or combination of therapies is more effective in improving upper limb functionality in post-stroke patients, thereby enhancing their quality of life and rehabilitation outcomes.

In this study, a randomized clinical trial (RCT) methodology will be utilized. 32 participants male and female patients aged 40 years and above who have a confirmed diagnosis of stroke, verified through CT scan and MRI imaging will be included. Eligible participants will have experienced a stroke within the past six months to ensure relevance to the intervention and recovery phase. Additionally, only those with a Brunnstrom grade of 2 or higher, indicating some degree of voluntary motor function, will be included by using non-probability convenience sampling and randomly divided into two groups: one receiving only CIMT and the other combining MT with CIMT. Baseline measurements will be taken for all participants to assess grip strength, hand dexterity, and upper limb motor function, utilizing validated tools like the Fugl-Meyer Assessment (FMA), Motor Activity Log (MAL), Box and Block Test (BBT), and Hand-Held Dynamometer. Both groups will undergo therapy sessions five days a week for six weeks, with daily sessions lasting 60-90 minutes. The data analysis will be performed using SPSS version 25. Data normality will be checked via the Shapiro-Wilk test. To evaluate within-group changes between pre- and post-treatment measurements, the Wilcoxon signed-rank test will be used, as it is appropriate for non-parametric data. The Mann-Whitney U test, a non-parametric test for comparing two independent groups.

Conditions

Stroke

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Constraint-Induced Movement Therapy

Constraint-Induced Movement Therapy (CIMT) will involve placing a mitt or sling on the unaffected upper limb to promote use of the affected arm. Participants will attend sessions 5 days a week for 6 weeks, each lasting 60-90 minutes.

Exercises include:

Squeezing therapy putty (3 sets of 10-15 reps) Isometric grip holds (3 sets of 5-10 seconds) Finger-tapping (3 sets of 10 reps) Buttoning and zipping tasks (3 sets of 5-10 reps) The intervention targets grip strength, endurance, dexterity, and functional motor recovery through moderate-intensity, task-specific training.

Group Type: EXPERIMENTAL

CONSTRAINT-INDUCED MOVEMENT THERAPY

Intervention Type: OTHER

Constraint-Induced Movement Therapy (CIMT) involves restricting the unaffected arm to promote use of the affected limb through task-specific exercises. It is delivered 5 days a week for 6 weeks, with sessions lasting 60-90 minutes, focusing on improving strength, dexterity, and function.

MIRROR THERAPY

The experimental group will receive Mirror Therapy for 15-20 minutes per session, 5 days a week for 6 weeks. A mirror will be placed to reflect movements of the unaffected limb, creating the illusion that the affected limb is moving. Participants will perform simulated grasping, finger tapping, pegboard tasks, and wrist movements to engage mirror neurons and promote motor recovery.

Group Type: EXPERIMENTAL

MIRROR THERAPY

Intervention Type: OTHER

Mirror Therapy (MT) uses a mirror to reflect movements of the unaffected limb, creating the illusion of movement in the affected limb.

Participants will do 60-90 minute sessions, 5 days a week for 6 weeks.

Exercises include hand opening/closing, finger movements, and simple object tasks to improve motor function and coordination through visual feedback.

Interventions

CONSTRAINT-INDUCED MOVEMENT THERAPY

Constraint-Induced Movement Therapy (CIMT) involves restricting the unaffected arm to promote use of the affected limb through task-specific exercises. It is delivered 5 days a week for 6 weeks, with sessions lasting 60-90 minutes, focusing on improving strength, dexterity, and function.

Intervention Type: OTHER

MIRROR THERAPY

Mirror Therapy (MT) uses a mirror to reflect movements of the unaffected limb, creating the illusion of movement in the affected limb.

Participants will do 60-90 minute sessions, 5 days a week for 6 weeks.

Exercises include hand opening/closing, finger movements, and simple object tasks to improve motor function and coordination through visual feedback.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Male and female patients
• Age 40 years and above
• Diagnosed patients confirmed by CT scan and MRI
• History of stroke not more than 6 months
• Brunnstrom grade 2 and above

Exclusion Criteria

• Patients having history of musculoskeletal disorders
• History of shoulder injuries or adhesive capsulitis
• Patients having visual and auditory deficit will be excluded
• Patients who have sensory deficit will be excluded

• Minimum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Riphah International University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

HAMZA NAFEES, MS-NMPT

Role: PRINCIPAL_INVESTIGATOR

Riphah International University

Locations

Evercare Hospital Lahore

Lahore, Punjab Province, Pakistan

Site Status: RECRUITING

Countries

Pakistan

Central Contacts

Asrar Yousaf, M.Phil

Role: CONTACT

Asrar.yousaf@riphah.edu.pk

+92 300 4099505

Facility Contacts

Adnan Arshad, DPT

Role: primary

dradnaanarshad@gmail.com

Other Identifiers

REC/RCR&AHS/24/0283

Identifier Type: -

Identifier Source: org_study_id