Improving Hand Use in Multiple Sclerosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

PHASE2

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-02-28

Study Completion Date

2016-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will compare two different kinds of physical therapy to improve use of the hands in individuals with multiple sclerosis (MS). One treatment will be Constraint-Induced Movement therapy (CI therapy), the other will be a set of Complementary and Alternative Medicine (CAM) treatments (yoga, relaxation exercises, aquatherapy, massage). The study will determine which of the two forms of treatment is more successful for improving hand use.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Comparing Mirror Therapy and CIMT for Hand and Arm Function in Post-Stroke Patients

NCT07139015

Stroke

RECRUITING NA

Telerehabilitation-based Upper Extremity Training in People With Multiple Sclerosis

NCT05073731

Multiple Sclerosis

UNKNOWN NA

Effectiveness of Telerehabilitation Interventions in Multiple Sclerosis

NCT05571826

Multiple Sclerosis

UNKNOWN

Investigation of the Effects of Technology Supported Different Physiotherapy Approaches on Patients With Multiple Sclerosis

NCT04891341

Multiple Sclerosis

COMPLETED NA

Upper Extremity Motor Imagery Functional Skills and Quality of Life in Patients With Multiple Sclerosis

NCT06572059

Multiple Sclerosis Upper Extremity Problem Quality of Life +2 more

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Multiple Sclerosis (MS) frequently causes reduced use of one of the hands, and as a result, much of daily living activities are conducted only by the other hand, leaving the person effective one-handed. Nonetheless, reduced hand use can be improved for extended amounts of time with specific forms of physical therapy, as long as persons with MS have the ability to perform the training tasks.

This study will randomize persons with MS who have relatively reduced use of one of the hands to either CI therapy or CAM treatments. Treatment in either program will be for 2 consecutive weeks, 3.5 hours per day (Monday-Friday), under the direct supervision of a specially trained therapist. Before starting, participants will also undergo comprehensive medical and physical exam screening and brain MRI scan. The same evaluations will be performed after treatment to learn whether any of these have changed as a result of treatment.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Multiple Sclerosis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

CI Therapy

CI therapy involves repetitive practice with the more-affected hand on typical daily living activities (such as stacking objects, pouring, moving objects) for 3.5 hours per day, along with physical restraint of the better hand to keep it from assisting, and home practice exercises.

Group Type ACTIVE_COMPARATOR

CI Therapy

Intervention Type BEHAVIORAL

CI Therapy will be given for 3.5 hours per day, Monday-Friday, for 2 consecutive weeks.

CAM treatments

CAM treatments are holistic physical treatments designed to work on the entire body to improve quality of life and overall health. This study will use yoga, relaxation exercises, aquatherapy (pool therapy), and massage.

Group Type ACTIVE_COMPARATOR

CAM treatments

Intervention Type BEHAVIORAL

CAM treatments will be given for 3.5 hours per day, Monday-Friday, for 2 consecutive weeks.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

CI Therapy

CI Therapy will be given for 3.5 hours per day, Monday-Friday, for 2 consecutive weeks.

Intervention Type BEHAVIORAL

CAM treatments

CAM treatments will be given for 3.5 hours per day, Monday-Friday, for 2 consecutive weeks.

Intervention Type BEHAVIORAL

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Constraint-Induced Movement therapy Complementary and Alternative Medicine

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* diagnosis of non-relapsing multiple sclerosis (primary progressive MS, secondary progressive MS)
* reduced use of one of the hands because of MS
* ability to pick up and release a small object with the more-affected hand when requested
* can travel to the treatment program at the University of Alabama at Birmingham (UAB)
* can undergo treatment for 2 weeks (Monday-Friday), 3.5 hours per day
* can undergo MRI scan
* any kind of medication used for MS is allowed except spasticity medicine

Exclusion Criteria

* disease relapse in the past 3 months
* pregnancy
* marked pain with arm movement
* severe uncontrolled medical illness
* simultaneous treatment with another form of physical therapy

Minimum Eligible Age

21 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No