Neural Mobilization on Multiple Sclerosis

NCT ID: NCT06153264

Last Updated: 2024-08-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-09-15
• Study Completion Date: 2024-07-15

Brief Summary

Current treatments for pain in MS patients include the use of non-pharmacological interventions such as electrotherapy and exercise, as well as pharmacological treatments. Neurodynamic mobilization exercises are an intervention that aims to restore homeostasis in and around the nervous system by activating the nervous system itself or the structures surrounding the nervous system. Neurodynamic mobilization facilitates movement between neural structures and their environment through manual techniques and exercise. Human and animal studies reveal that neurodynamic mobilization reduces intraneural edema, improves intraneural fluid distribution, reduces thermal and mechanical hyperalgesia, and reverses increased immune responses following a nerve injury.

Detailed Description

Multiple Sclerosis (MS) is a chronic neurological disease characterized by local inflammation, gliosis and demyelination in the central nervous system (CNS). It is characterized by demyelinating plaques seen in the brain and medulla spinalis. Many different symptoms can be seen depending on the affected areas in the CNS. One of the common symptoms in these patients is pain. Approximately 50% of patients complain of pain at some point in their lives, and in 20% of them, pain is one of the initial symptoms. Pain may originate from the musculoskeletal system; It may also develop due to inflammation and upper motor neuron damage and may have a neuropathic character. As a result, pain in MS negatively affects patients' physical, emotional functions and quality of life.

Current treatments for pain in MS patients include the use of non-pharmacological interventions such as electrotherapy and exercise, as well as pharmacological treatments. Neurodynamic mobilization exercises are an intervention that aims to restore homeostasis in and around the nervous system by activating the nervous system itself or the structures surrounding the nervous system. Neurodynamic mobilization facilitates movement between neural structures and their environment through manual techniques and exercise. Human and animal studies reveal that neurodynamic mobilization reduces intraneural edema, improves intraneural fluid distribution, reduces thermal and mechanical hyperalgesia, and reverses increased immune responses following a nerve injury.

As a result of this study, it is thought that the determination of effective treatment methods for pain, which is a common symptom of MS patients, will increase the patient's muscle strength and dexterity.

The aim of the study is to examine the effects of neurodynamic mobilization exercises on pain, muscle strength and dexterity in Multiple Sclerosis patients.

Conditions

Multiple Sclerosis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Control Group

Upper extremity strengthening exercises will be applied 10 repetitions a day, 3 days a week for 6 weeks.

Group Type: EXPERIMENTAL

strengthening exercises

Intervention Type: OTHER

upper extremity strengthening exercises will be applied 10 repetitions a day, 3 days a week for 6 weeks

Study Group

Upper extremity neurodynamic mobilization exercises and upper extremity strengthening exercises will be applied 10 repetitions a day, 3 days a week for 6 weeks.

Group Type: EXPERIMENTAL

neurodynamic mobilization exercise

Intervention Type: OTHER

Upper extremity neurodynamic mobilization exercises and upper extremity strengthening exercises will be applied 10 repetitions a day, 3 days a week for 6 weeks.

strengthening exercises

Intervention Type: OTHER

upper extremity strengthening exercises will be applied 10 repetitions a day, 3 days a week for 6 weeks

Interventions

neurodynamic mobilization exercise

Upper extremity neurodynamic mobilization exercises and upper extremity strengthening exercises will be applied 10 repetitions a day, 3 days a week for 6 weeks.

Intervention Type: OTHER

strengthening exercises

upper extremity strengthening exercises will be applied 10 repetitions a day, 3 days a week for 6 weeks

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

1. Being diagnosed with MS according to McDonald 2010 diagnostic criteria

2. Being between the ages of 18-65

3. Volunteering to participate in the study

Exclusion Criteria

1. Being under 18 years of age and over 65 years of age

2. Having a history of trauma within the last year

3. Having alcohol and substance addiction

4. Having diabetes mellitus

5. Having another known neurological disease

6. Being pregnant

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Kahramanmaras Sutcu Imam University

OTHER

Sponsor Role: lead

Responsible Party

Zekiye İpek KATIRCI KIRMACI

Asst. Prof

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Zekiye İpek Katırcı Kırmacı

Role: PRINCIPAL_INVESTIGATOR

Kahramanmaras Sütçü İmam University

Locations

Kahramanmaras Sutcu Imam University

Kahramanmaraş, , Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

ipek.kirmaci

Identifier Type: -

Identifier Source: org_study_id