Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors
NCT ID: NCT07123740
Last Updated: 2025-08-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2025-08-18
2026-07-24
Brief Summary
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Regional anesthesia techniques, such as intrathecal morphine and erector spinae plane block, have been utilized to enhance postoperative analgesia and reduce perioperative opioid requirements, potentially minimizing opioid-related adverse effects.
In this study, we aimed to compare the postoperative analgesic efficacy of intrathecal morphine and Bi-level erector spinae plane block in living liver donors.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Intrathecal Morphine
An intrathecal injection of morphine 300μg will be administered at the L3-L4 or L4-L5 level.
In the intraoperative period, intravenous meperidine 0.5 mg/kg will be given 30min before the end of surgery.
Intrathecal Morphine
An intrathecal injection of morphine 300μg will be administered at the L3-L4 or L4-L5 level.
Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.
Bi-level Erector Spinae Plane Block
After the linear ultrasound (US) probe will be placed 2-3 cm lateral to the T8 spinous process, 10 ml of 0.25% bupivacaine hydrochloride will be injected cauda-cranially into the interfacial space below the erector spinae muscle, above the transverse process. Next, the needle will be withdrawn till subcutaneously and the linear US probe will be placed 2-3 cm lateral to the T10 spinous process. Finally, 10 ml of 0.25% bupivacaine hydrochloride will be injected cranio-caudally into the interfacial space below the erector spinae muscle, above the transverse process.
This procedure will be performed bilaterally. A total of 40 ml of 0.25% bupivacaine will be injected for bilateral and bi-level ESPB application.
In the intraoperative period, intravenous meperidine 0.5 mg/kg will be given 30min before the end of surgery.
Bi-level Erector Spinae Plane Block
Bi-level erector spinae plane block will be performed on the patients using a total of 40 ml of 0.25% bupivacaine under ultrasound guidance.
Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.
Interventions
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Intrathecal Morphine
An intrathecal injection of morphine 300μg will be administered at the L3-L4 or L4-L5 level.
Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.
Bi-level Erector Spinae Plane Block
Bi-level erector spinae plane block will be performed on the patients using a total of 40 ml of 0.25% bupivacaine under ultrasound guidance.
Additionally, in the postoperative period a dexketoprofen dose of 50 mg twice daily were administered iv for multimodal analgesia.
Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists (ASA) score I-II
* Body Mass Index (BMI) between 18-30 kg/m2
Exclusion Criteria
* ASA score III and above
* Patients with a history of bleeding diathesis
* BMI below 18 or above 30 kg/m2
18 Years
65 Years
ALL
No
Sponsors
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Ankara Etlik City Hospital
OTHER_GOV
Responsible Party
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Atakan Sezgi
Principal Investigator
Locations
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Ankara Etlik City Hospital
Altındağ, Ankara, Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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AEŞH-EK-2025-155
Identifier Type: -
Identifier Source: org_study_id
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