External Oblique Intercostal Plane Block for Liver Transplantation Recipient
NCT ID: NCT07233083
Last Updated: 2026-01-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2025-12-22
2026-06-30
Brief Summary
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The aim of this study is to investigate the postoperative analgesic efficacy of the external oblique intercostal plane block in liver transplant recipients.
The investigators will compare a group receiving the external oblique intercostal plane block with a control group to determine whether this block provides effective postoperative analgesia in liver transplant recipients.
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Detailed Description
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Patients in the External Oblique Intercostal Plane Block Group will be performed bilateral External Oblique Intercostal Plane Block at the end of the surgery and after skin closure and will receive patient controlled analgesia with morphine for postoperative analgesia.
Patients in the Control Group will not receive any block procedure and will receive patient controlled analgesia with morphine for postoperative analgesia.
Morphine consumption for first postoperative 48 hours, visual analog scale scores, time to need for first rescue analgesia, amount of rescue analgesic drug, incidence of postoperative nausea and vomiting, and Quality of Recovery-15 scores will be recorded.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
DOUBLE
Study Groups
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External oblique intercostal plane block group
The patients in the External Oblique Intercostal Plane Block group will receive bilateral external oblique intercostal plane block and patient controlled analgesia (PCA) with morphine for postoperative analgesia.
External Oblique Intercostal Plane Block
External oblique intercostal plane block will be administered at the end of the surgery and after skin closure
Control Group
The patients in the Control group will not receive any regional block and will receive patient controlled analgesia (PCA) with morphine for postoperative analgesia.
Sham Procedure
Sham Block (Ultrasound probe placement without needle insertion or injection)
Interventions
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External Oblique Intercostal Plane Block
External oblique intercostal plane block will be administered at the end of the surgery and after skin closure
Sham Procedure
Sham Block (Ultrasound probe placement without needle insertion or injection)
Eligibility Criteria
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Inclusion Criteria
* Scheduled for elective orthotopic liver transplantation (living or deceased donor)
* J-shaped or Mercedes incision planned
* ASA physical status III-IV
* Normal or acceptable coagulation profile at the time of block application (INR ≤ 1.5, platelet count ≥ 50,000/mm³, fibrinogen ≥ 150 mg/dL)
* Able to provide written informed consent
Exclusion Criteria
* Known allergy or hypersensitivity to local anesthetics (amide group)
* Local infection or skin lesion at the block injection site
* Severe hemodynamic instability requiring high-dose vasopressor support
* Chronic opioid use (≥30 mg oral morphine equivalents per day for ≥30 days before surgery)
* Severe hepatic encephalopathy or cognitive impairment preventing use of PCA or pain scoring
* Emergency or re-transplantation surgery
18 Years
75 Years
ALL
No
Sponsors
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Istinye University
OTHER
Responsible Party
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Locations
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istinye University
Istanbul, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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anestezi 5
Identifier Type: -
Identifier Source: org_study_id
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