Carbohydrate Mouth Rinsing and Cognitive Response During Exercise

NCT ID: NCT07099807

Last Updated: 2025-08-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 11 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-02-28
• Study Completion Date: 2025-05-17

Brief Summary

This study investigates whether rinsing the mouth with a carbohydrate solution can improve brain oxygenation and cognitive function during high-intensity exercise. Eleven trained cyclists participated in multiple exercise sessions under different mouth rinse conditions. Brain oxygenation, perceived exertion, and cognitive performance were measured. The goal is to understand if this simple technique can support both physical and mental performance during demanding exercise.

Conditions

Exercise Performance of Fit Athletes

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: DOUBLE

Study Groups

Carbohydrate Mouth Rinse

Group Type: EXPERIMENTAL

Carbohydrate Mouth Rinse

Intervention Type: BEHAVIORAL

A 6.4% maltodextrin solution (64 g/L) was prepared using Nutricost Maltodextrin Powder. Participants performed five mouth rinses per trial, each using 25 mL of the solution for 10 seconds before expectorating. Each rinse was followed by a 30-second rest. Participants were instructed not to swallow the solution. Rinsing procedure was standardized across all sessions.

Placebo Mouth Rinse

Group Type: PLACEBO_COMPARATOR

Placebo Mouth Rinse

Intervention Type: BEHAVIORAL

A placebo solution containing 0.05 g/L of non-caloric sucralose in distilled water was used to match sweetness and viscosity of the CHO-MR. Participants performed five rinses of 25 mL for 10 seconds each, spitting out the solution after each rinse. 30-second rest intervals followed each rinse. Swallowing was not allowed. Rinse frequency, volume, and duration were standardized.

Music Listening

Group Type: EXPERIMENTAL

Music Listening

Intervention Type: BEHAVIORAL

Participants listened to high-tempo music (120 bpm) for 15 minutes before exercise using standardized earbuds. Music was selected from a public YouTube playlist titled "120 BPM Best Dance Music for Running and Working Out." Volume was calibrated at 65 dB (50% of max device volume). Auditory conditions were standardized across all participants.

Interventions

Carbohydrate Mouth Rinse

A 6.4% maltodextrin solution (64 g/L) was prepared using Nutricost Maltodextrin Powder. Participants performed five mouth rinses per trial, each using 25 mL of the solution for 10 seconds before expectorating. Each rinse was followed by a 30-second rest. Participants were instructed not to swallow the solution. Rinsing procedure was standardized across all sessions.

Intervention Type: BEHAVIORAL

Placebo Mouth Rinse

A placebo solution containing 0.05 g/L of non-caloric sucralose in distilled water was used to match sweetness and viscosity of the CHO-MR. Participants performed five rinses of 25 mL for 10 seconds each, spitting out the solution after each rinse. 30-second rest intervals followed each rinse. Swallowing was not allowed. Rinse frequency, volume, and duration were standardized.

Intervention Type: BEHAVIORAL

Music Listening

Participants listened to high-tempo music (120 bpm) for 15 minutes before exercise using standardized earbuds. Music was selected from a public YouTube playlist titled "120 BPM Best Dance Music for Running and Working Out." Volume was calibrated at 65 dB (50% of max device volume). Auditory conditions were standardized across all participants.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Aged between 20 and 30 years
• Engaged in regular cycling training (≥5 sessions per week, ~4 hours per day)
• No known cardiovascular, neurological, or metabolic diseases
• Provided written informed consent

Exclusion Criteria

• Current use of medication affecting cardiovascular or cognitive function
• Recent musculoskeletal injuries that affect cycling ability
• Smoking or excessive alcohol consumption
• Refusal or inability to comply with study procedures

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

CHA University

OTHER

Sponsor Role: lead

Responsible Party

Park Seung-Bo

CHA Bundang Medical Center

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Seung-Bo Park

Role: PRINCIPAL_INVESTIGATOR

CHA University

Locations

CHA University, Human Performance Lab

Seongnam-si, Gyeonggi-do, South Korea

Countries

South Korea

Other Identifiers

Parks0524

Identifier Type: -

Identifier Source: org_study_id