Multiomics Profiling of CSF in Cardiac Arrest Survivors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-07-22

Study Completion Date

2026-12-31

Brief Summary

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The goal of this observational study is to identify further pathophysiologic mechanism of secondary brain injury following cardiac arrest by using serial multiomics profiling of serum and cerebrospinal fluid (CSF) samples. The main question it aims to answer is:

A. The main question it aims to answer is: What are the dynamic molecular changes in serum and CSF that reflect the pathophysiological mechanisms of secondary brain injury after cardiac arrest? B. What are the differences in serum and CSF multiomic signatures between varying severities of cardiac arrest, and how are these differences associated with the underlying pathophysiological mechanisms of secondary brain injury?

Serum and CSF samples that have already been prospectively collected from participants and stored in the BioBank will be used for this analysis.

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Detailed Description

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Conditions

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Cardiac Arrest (CA) Hypoxic-Ischemic Brain Injury Post-Resuscitation Syndrome

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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good neurologic outcome

Cerebral Performance Category (CPC) : 1 or 2

No interventions assigned to this group

poor neurologic outcome

Cerebral Performance Category (CPC) : 3 to 5

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years old
* Out-of-hospital cardiac arrest (OHCA)
* Patients who have received post-resuscitation care including temperature control due to unconsciousness (Glasgow Coma Score \< 8) after sustained ROSC.
* Patients who consented to the placement of lumbar catheter for storing cerebrospinal fluid and blood samples in a human biobank.

Exclusion Criteria

* Patients diagnosed with a central nervous system-related disease before cardiac arrest
* Patients who have undergone extracorporeal circulatory membrane oxygenation therapy
* Patients who died within 24 hours from post-resuscitation care

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No