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Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation

NCT ID: NCT03609333

Last Updated: 2020-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-12

Study Completion Date

2020-06-30

Brief Summary

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Hypoxic ischemic brain injury is a devastating illness that occurs after cardiac arrest (the heart stopping) and can yield irreversible brain damage, often leading to death. The mainstay in therapy is to optimize the delivery of oxygen to the brain to help it recover. In patients with traumatic brain injury (similar to HIBI), the investigators are able to optimize oxygen delivery to the brain with the use of wires placed into the brain that sense the pressure and oxygen in the skull to find the ideal blood pressure for each individual patient. This strategy is associated with improved outcomes. The investigators are conducting a prospective study investigating whether the perfusion within proximity to the optimal MAP is associated with improved brain oxygenation and blood flow .

Detailed Description

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Conditions

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Cardiac Arrest

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Study Groups

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Internal arm

Group Type EXPERIMENTAL

Multimodal Neuromonitoring

Intervention Type DEVICE

Application of multimodal neuromonitoring

Interventions

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Multimodal Neuromonitoring

Application of multimodal neuromonitoring

Intervention Type DEVICE

Other Intervention Names

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Targeted optimal MAP resuscitation

Eligibility Criteria

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Inclusion Criteria

* Confirmed cardiac arrest with return of spontaneous circulation \> 10 minutes
* post resuscitation GCS \< 9

Exclusion Criteria

* concurrent coagulopathy
* prior history of TBI, intracranial hemorrhage, subarachnoid hemorrhage
* anticipated cardiac catheterization within next 7 days
* anticipated or current use of anticoagulants or anit-platelets
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of British Columbia

OTHER

Sponsor Role lead

Responsible Party

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Myp Sekhon

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mypinder Sekhon, MD

Role: PRINCIPAL_INVESTIGATOR

UBC

Locations

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Vancouver General Hospital

Vancouver, British Columbia, Canada

Site Status

Countries

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Canada

References

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Sekhon MS, Ainslie PN, Menon DK, Thiara SS, Cardim D, Gupta AK, Hoiland RL, Gooderham P, Griesdale DE. Brain Hypoxia Secondary to Diffusion Limitation in Hypoxic Ischemic Brain Injury Postcardiac Arrest. Crit Care Med. 2020 Mar;48(3):378-384. doi: 10.1097/CCM.0000000000004138.

Reference Type DERIVED
PMID: 31789834 (View on PubMed)

Sekhon MS, Griesdale DE, Ainslie PN, Gooderham P, Foster D, Czosnyka M, Robba C, Cardim D. Intracranial pressure and compliance in hypoxic ischemic brain injury patients after cardiac arrest. Resuscitation. 2019 Aug;141:96-103. doi: 10.1016/j.resuscitation.2019.05.036. Epub 2019 Jun 8.

Reference Type DERIVED
PMID: 31185256 (View on PubMed)

Other Identifiers

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H16-00466

Identifier Type: -

Identifier Source: org_study_id