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CARbon monoxidE intoxiCatiOn in Korea: Prospective Cohort (CARE CO Cohort)

NCT ID: NCT04490317

Last Updated: 2024-07-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

1500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-07-29

Study Completion Date

2035-12-31

Brief Summary

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This prospective cohort study enrolls subjects who experience carbon monoxide (CO) poisoning. The purpose of the study is to evaluate therapeutic effects of various treatments and short and long-term outcomes in CO poisoned patients. In addition, complications of brain and heart susceptible to CO are investigated through various ways and the association between complications and the patient's prognosis is also investigated. All subjects will be regularly monitored by physicians participating in this study.

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Detailed Description

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This prospective cohort study enrolls subjects who experience CO poisoning. The purpose of the study is to evaluate therapeutic effects of various treatments, including hyperbaric oxygen therapy (HBO), therapeutic hypothermia (TH), and additional drugs, and short and long-term outcomes, such as neurocognitive sequelae or mortality, in CO poisoned patients. In addition, complications of brain and heart susceptible to CO are investigated through a variety of ways, such as magnetic resonance image (MRI), computed tomography (CT), ultrasound, and laboratory test, and the association between various complications and the patient's prognosis is also investigated. All subjects will be regularly monitored by physicians participating in this study.

Conditions

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Carbon Monoxide Poisoning Myocardial Injury Neurologic Deficits Image, Body Therapy Prognostic Factors Complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Acute CO poisoning

A diagnosis of CO poisoning is made according to medical history and carboxyhemoglobin \>5% (\>10% in smokers).

Cardiac MRI

Intervention Type DIAGNOSTIC_TEST

1. Cardiac MRI be taken to CO poisoned patients
2. Cardiac CT be taken to CO poisoned patients
3. TTE be taken to CO poisoned patients
4. Brain MRI be taken to CO poisoned patients
5. Neurocognitive function tests be taken to CO poisoned patients
6. Laboratory tests be taken to CO poisoned patients

Hyperbaric oxygen therapy

Intervention Type PROCEDURE

1. Hyperbaric oxygen therapy be used for CO poisoned patients
2. Therapeutic hypothermia be used for CO poisoned patients

Interventions

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Cardiac MRI

1. Cardiac MRI be taken to CO poisoned patients
2. Cardiac CT be taken to CO poisoned patients
3. TTE be taken to CO poisoned patients
4. Brain MRI be taken to CO poisoned patients
5. Neurocognitive function tests be taken to CO poisoned patients
6. Laboratory tests be taken to CO poisoned patients

Intervention Type DIAGNOSTIC_TEST

Hyperbaric oxygen therapy

1. Hyperbaric oxygen therapy be used for CO poisoned patients
2. Therapeutic hypothermia be used for CO poisoned patients

Intervention Type PROCEDURE

Other Intervention Names

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Cardiac CT Transthoracic echocardiography (TTE) Brain MRI Neurocognitive function tests Laboratory tests Therapeutic hypothermia

Eligibility Criteria

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Inclusion Criteria

* Acute CO poisoning

Exclusion Criteria

* Declined to enrollment in the study
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Wonju Severance Christian Hospital

OTHER

Sponsor Role lead

Responsible Party

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Yong Sung Cha

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yong Sung Cha, MD

Role: PRINCIPAL_INVESTIGATOR

Wonju Severance Christian Hospital

Locations

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Wonju Severance Christian Hospital

Wŏnju, Gangwon-do, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Yong Sung Cha, MD

Role: CONTACT

[email protected]
+82-33-741-1615

Facility Contacts

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Yong Sung Cha, MD

Role: primary

[email protected]
+82-33-741-1615

References

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Ahn GJ, Lee S, Heo YW, Cha YS. Mortality Risks and Causes in Previous Carbon Monoxide Poisoning: A Nationwide Population-Based Cohort Study. Crit Care Med. 2024 Dec 1;52(12):1866-1876. doi: 10.1097/CCM.0000000000006414. Epub 2024 Sep 18.

Reference Type DERIVED
PMID: 39298511 (View on PubMed)

Other Identifiers

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CARE CO cohort

Identifier Type: -

Identifier Source: org_study_id

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