TAC, SOD and MDA Responses to Aerobic Exercise Versus Phoenix Seed in Obese Sedentary Females

NCT ID: NCT07073716

Last Updated: 2025-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-07-10

Study Completion Date

2025-11-10

Brief Summary

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the aim of this study is To assess the antioxidant potential by measuring TAC, SOD and MDA responses to aerobic exercise versus phoenix seed in 60 obese sedentary females with symptoms of systemic inflammation. • All subjects will follow the given instructions strictly during the study duration, regarding the assessment and the treatment procedure, all participants will be evaluated under the same environmental conditions

Detailed Description

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reactive oxygen species (ROS) are generated as metabolic by-products by biological systems during Processes like protein phosphorylation, activation of several transcriptional factors, apoptosis, immunity, and differentiation. When ROS production increases, they start showing harmful effects on important cellular structures like proteins, lipids, and nucleic acids. A large body of evidences shows that oxidative stress can be responsible, with different degrees of importance in the onset and/or progression of several diseases as cancer, diabetes, metabolic disorders, atherosclerosis, and cardiovascular diseases.

Date seed is a waste product that is high in polyphenolics (a mjor antioxidant compounds), phenolicacid (allergic, epicatechin, catechol,chlorogenic), carotenoids, total dietary fiber (such as pectin, β-glucan, and arabinoxylan), fat, protein, minerals, and various other nutrients and functional elements Phytosterols as β-sitosterol, campesterol, and Δ5-avenasterol are The major components of date seed oil sterols (contents varied between 4.70 and 8.45 mg/g) are important micronutrients and essential structural components of the cellular membrane.they serve crucial functions, such as modulating membrane permeability and fluidity, antioxidant activity , cholesterol-lowering effects and anti-inflammatory properties in addition to their putative contribution to reducing the risk of cardiovascular diseases and affording benefits to the immune system.

Physical activity improves antioxidant defences, lowers lipid peroxidation levels and involved in the protection from cardiovascular disorders, type II diabetes, metabolic syndrome and neurodegenerative diseases like Alzheimer's disease both in adult and in aged individuals. Thus emphasizing the importance of regular physical activity to decelerate the aging-associated impairment process.

Myokines,the bioactive peptides released by skeletal muscle following exercise as acrucial regulator of metabolic and protective pathways in peripheral tissues, particularly in combating oxidative stress and inflammation through activating intracellular signalling pathways within the liver that are involved in the liver's antioxidant defences.

this study aims to compare between aerobic exercise and phoenix seed in their antioxidant potential.

Conditions

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Aerobic Exercise Phoenix Seed, Antioxidant Potential

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Aerobic exercise

20 subjects performed a specialized program of aerobic exercise with frequency of 3-5 times /week

Group Type EXPERIMENTAL

aerobic exercise

Intervention Type OTHER

the exercise protocol was applied following these characteristics

* frequency: 3-5 times /week along the whole study period
* intensity: 70% of the maximal heart rate (220- age x 70/100)
* duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training.

phoenix seed

20 subjects performed specialized program of phoenix seed consumption

Group Type EXPERIMENTAL

phoenix seed

Intervention Type DIETARY_SUPPLEMENT

consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day

Aerobic exercise and phoenix seed

20 subjects performed the same program of aerobic exercise with same frequency of 3-5 times /weeks combined with the same program of phoenix seed consumption

Group Type EXPERIMENTAL

aerobic exercise+ phoenix seed

Intervention Type COMBINATION_PRODUCT

a specialized programme of aerobic exercise.the exercise protocol follow these characteristics

* frequency: 3-5 times /week along the whole study period
* intensity: 70% of the maximal heart rate (220- age x 70/100)
* duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training.

the specialized program of phoenix seed consumption (consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day)

Interventions

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aerobic exercise

the exercise protocol was applied following these characteristics

* frequency: 3-5 times /week along the whole study period
* intensity: 70% of the maximal heart rate (220- age x 70/100)
* duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training.

Intervention Type OTHER

phoenix seed

consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day

Intervention Type DIETARY_SUPPLEMENT

aerobic exercise+ phoenix seed

a specialized programme of aerobic exercise.the exercise protocol follow these characteristics

* frequency: 3-5 times /week along the whole study period
* intensity: 70% of the maximal heart rate (220- age x 70/100)
* duration: 50 min (warming up exercise movements (stretching and flexibility) in standing position, active phase of walking on a computerized treadmill, cooling down exercise movements (stretching and flexibility) performed in the seated position. being supervised by two trainers and the researcher. The researcher controlled the heartbeat 2 times through carotid pulse and At the end in order to restore the body to its initial state. all the patients could drink water during their training.

the specialized program of phoenix seed consumption (consuming 2 grams of phoenix seed powder dissolved in about 100 ml water 3 times/day)

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

\-
Minimum Eligible Age

35 Years

Maximum Eligible Age

55 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Zainab Saeed Aly

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Zainab Saeed Aly, lecturer at Horus university

Role: CONTACT

+201003859679 ext. 01285512452

nagwa ammar, professor of pharmacognosy

Role: CONTACT

01227943502

Other Identifiers

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R.T.REC/012/005432

Identifier Type: -

Identifier Source: org_study_id

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