Impact of Exercise Combined With Inulin Propionate Ester on Fat Oxidation

NCT ID: NCT04016350

Last Updated: 2019-07-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-02-05
• Study Completion Date: 2017-06-11

Brief Summary

There is evidence to suggest that responsiveness to exercise training programmes can be expected to be influenced by changes in resting fat oxidation, an important factor in the aetiology of obesity. Our previous work has shown that oral supplementation with inulin propionate ester (IPE) reduces intra-abdominal fat and prevents weight gain and that oral propionate intake enhances resting fat oxidation. The effects of IPE combined with exercise training on resting fat oxidation and body fatness are unknown. The aim of this study was to investigate the impact of 4-weeks IPE supplementation, in combination with a moderate intensity exercise training programme, on whole body fat oxidation and on plasma GLP-1 and PYY.

Detailed Description

Participants: Healthy overweight females with BMI >25 kg/m2 and 25-45 years of age were recruited through advertisements and word of mouth on the campus of the University of Glasgow or from other public places. Participants were required to be sedentary, non-smokers, with stable body weight for two months prior to the study enrollment, not pregnant, free of medication, nutritional supplementation or following any specific diet and with no antibiotic use for the past three months. Participants with chronic illness, eating disorders and history of gastrointestinal operations were excluded.

Study Design: This is a randomized study with a parallel design. Study participants underwent 4 week supervised moderate intensity exercise training combined either with IPE (EX/IPE) or cellulose as placebo (EX/Placebo) supplementation at doses of 10g / day. Supplements were provided as sachets containing white powder and participants were asked to consume one sachet per day with breakfast in a way convenient for each participant. Before the start of the study and at the end of the 4-week intervention, participants were asked to conduct a submaximal exercise test. Prior to the first and after the second submaximal exercise test, participants of both groups conducted a 7-hour experimental trial which involved collection of expired air and blood samples in fasted and postprandial states. Body weight and body composition were measured in the fasted state. Prior to the first 7-hour experimental trial, participants were asked to record their diet for 3 days and replicate this intake prior to the second 7-hour experimental trial.

Conditions

Exercise; Inulin Propionate Ester

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Exercise Training with Inulin Propionate Ester

Study participants underwent 4 week supervised moderate intensity exercise training combined with Inulin Propionate Ester supplementation at doses of 10g / day.

Group Type: EXPERIMENTAL

Exercise training with Inulin Propionate Ester

Intervention Type: BEHAVIORAL

Supervised moderate intensity exercise training combined with Inulin Propionate Ester supplementation conducted for 4 weeks.

Exercise Training with Placebo

Study participants underwent 4 week supervised moderate intensity exercise training combined with cellulose as placebo at doses of 10g / day.

Group Type: EXPERIMENTAL

Exercise training with placebo

Intervention Type: BEHAVIORAL

Supervised moderate intensity exercise training combined with placebo conducted for 4 weeks

Interventions

Exercise training with Inulin Propionate Ester

Supervised moderate intensity exercise training combined with Inulin Propionate Ester supplementation conducted for 4 weeks.

Intervention Type: BEHAVIORAL

Exercise training with placebo

Supervised moderate intensity exercise training combined with placebo conducted for 4 weeks

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

Healthy, sedentary and overweight females with BMI >25 kg/m2 and stable body weight for two months prior to the study.

Exclusion Criteria

Acute or chronic illness, eating disorders, history of gastrointestinal operations, smoking, pregnancy, taking supplements, and being on specific diet for the past three months.

• Minimum Eligible Age: 25 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Glasgow

OTHER

Sponsor Role: lead

Responsible Party

Dr Dalia Malkova

Senior Lecturer

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Douglas Morrison, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Glasgow

References

Malkova D, Polyviou T, Rizou E, Gerasimidis K, Chambers ES, Preston T, Tedford MC, Frost G, Morrison DJ. Moderate intensity exercise training combined with inulin-propionate ester supplementation increases whole body resting fat oxidation in overweight women. Metabolism. 2020 Mar;104:154043. doi: 10.1016/j.metabol.2019.154043. Epub 2019 Nov 29.

Reference Type: DERIVED

PMID: 31790692 (View on PubMed)

Other Identifiers

BB/L004259/1

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

UGlasgow IPE

Identifier Type: -

Identifier Source: org_study_id