Ischemia Reperfusion: Prostaglandins and Antioxidants

NCT ID: NCT01666587

Last Updated: 2017-05-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-08-31

Study Completion Date

2013-08-31

Brief Summary

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The purposes of this study are two-fold. The first purpose is to determine the effect of taking vitamins on the recovery of an artery (blood vessel) following an induced temporary injury. The second purpose is to determine whether a specific vasodilator is less abundant after the injury and whether this contributes to increased constriction or after the injury. Finally, does vitamin consumption have an effect on the recovery from the injury if one of the substances in the blood that causes vessels to enlarge (dilate) is stopped?

Detailed Description

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Conditions

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Ischemic Reperfusion Injury

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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control

Control trial to determine the impact of the ischemic injury on vascular function without intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Antioxidant load

Trial to determine the impact of an antioxidant load before the ischemic injury on vascular function recovery

Group Type EXPERIMENTAL

Antioxidant

Intervention Type DIETARY_SUPPLEMENT

Prostaglandin inhibition

Trial to determine the impact of a non-selective prostaglandin inhibitor before the ischemic injury on vascular function recovery

Group Type EXPERIMENTAL

Prostaglandin inhibitor (Ibuprophen)

Intervention Type DRUG

Combined

Trial to determine the impact of an antioxidant load and prostaglandin inhibitor before the ischemic injury on vascular function recovery

Group Type EXPERIMENTAL

Antioxidant

Intervention Type DIETARY_SUPPLEMENT

Prostaglandin inhibitor (Ibuprophen)

Intervention Type DRUG

Interventions

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Antioxidant

Intervention Type DIETARY_SUPPLEMENT

Prostaglandin inhibitor (Ibuprophen)

Intervention Type DRUG

Other Intervention Names

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ibuprofen

Eligibility Criteria

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Inclusion Criteria

* Healthy males
* Healthy females

Exclusion Criteria

* Smokers
* Cardiovascular disease
* Peripheral vascular disease
* Neurological deficits
* Diabetes Type I or II
* Pregnant women
* Adverse reactions to Ibuprofen
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Essex

OTHER

Sponsor Role lead

Responsible Party

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Mark Rakobowchuk

Principle Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mark Rakobowchuk, PhD

Role: PRINCIPAL_INVESTIGATOR

Thompson Rivers University

Locations

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University of Essex

Colchester, Essex, United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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DBD0300

Identifier Type: OTHER

Identifier Source: secondary_id

IRAPC

Identifier Type: -

Identifier Source: org_study_id

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