CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia

NCT ID: NCT07072975

Last Updated: 2025-10-01

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-10-31
• Study Completion Date: 2027-08-31

Brief Summary

Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses.

this randomized, controlled, study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.

Hypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.

Conditions

Intermittent Hypoxia; Exercise Recovery; Intermittent Exercise; Rating Exertion Perception; Sleep

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

comparator

On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.

Group Type: EXPERIMENTAL

Normobaric hypoxia

Intervention Type: OTHER

Normobaric hypoxia (inspired oxygen fraction of 12.9%) applied between-sets recovery periods

sham

Group Type: SHAM_COMPARATOR

normoxic condition

Intervention Type: OTHER

Between-sets recovery periods under normoxic condition

Interventions

Normobaric hypoxia

Normobaric hypoxia (inspired oxygen fraction of 12.9%) applied between-sets recovery periods

Intervention Type: OTHER

normoxic condition

Between-sets recovery periods under normoxic condition

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• from 40 to 60 years
• follow-up in the pneumology unit of CHU Amiens - Picardie
• Chronic Obstructive Pulmonary Disease stade II
• Body mass index from 20 to 30 kg.m-2
• Tiffeneau index < 70% of predicted value
• FEV1 from 50 to 80% of predicted values
• Smoking cessation since at least 1 week
• Sedentary or physical active
• Affiliate to social security
• Written consent

Exclusion Criteria

-

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Centre Hospitalier Universitaire, Amiens

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

CHRU Amiens

Amiens, , France

Countries

France

Central Contacts

Emeric Thiesset, MD

Role: CONTACT

thiesset.emeric@chu-amiens.fr

33+322088051

Facility Contacts

Emeric Thiesset, MD

Role: primary

Thiesset.emeric@chu-amiens.fr

33+3 22 08 80 51

Other Identifiers

PI2025_843_0029

Identifier Type: -

Identifier Source: org_study_id