The Role of Resistance Exercise in Chronic Obstructive Pulmonary Disease Exacerbation

NCT ID: NCT01786928

Last Updated: 2013-02-08

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 34 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-04-30
• Study Completion Date: 2010-10-31

Brief Summary

The purpose of this study is to determine whether resistance exercise are effective in combating the decline in muscle strength during an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).

Detailed Description

Acute exacerbations are common in patients with COPD and cause specific signs and symptoms, such as increased dyspnea, productive cough with altered sputum, and fever. With disease progression, exacerbations are frequent and have a negative impact on health related quality of life and pulmonary function as well as increase mortality. More severe exacerbations require hospitalization resulting in enormous health expenditures, severely reducing daily life activities and declining peripheral muscle strength that can be only partially reversed after 3 months. Despite many features have been pointed out as responsible for the decrease in muscle strength during hospitalization, physical inactivity seems the most important.

Resistance training is an interesting therapeutic option to prevent and/or reverse muscular dysfunction due to immobilised in healthy subjects and stable COPD patients because induces hypertrophy of type II fibers, increases muscle strength and exercise tolerance. In addition, provokes lower dyspnea perception during effort compared with other exercise training. Despite these benefits for stable COPD, the impact of a resistance exercise program during hospitalization remains poorly known.

Conditions

Chronic Obstructive Pulmonary Disease

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

resistance training

resistance training of the upper and lower limbs, two series of 80% of repetition maximum test

Group Type: EXPERIMENTAL

Resistance training

Intervention Type: OTHER

Resistance training group received training program for upper (shoulder flexion and abduction and biceps) and lower limbs (knee extension and flexion and hip flexion). Daily exercise for every muscle was performed with free weights at 80% of an maximal repetition test and a 4 minutes rest was allowed between each step.

Control

Traditional Respiratory Therapy for bronchial hygiene

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Resistance training

Resistance training group received training program for upper (shoulder flexion and abduction and biceps) and lower limbs (knee extension and flexion and hip flexion). Daily exercise for every muscle was performed with free weights at 80% of an maximal repetition test and a 4 minutes rest was allowed between each step.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• patients hospitalized for exacerbation of COPD

Exclusion Criteria

• patients presenting change in mental status (confusion, lethargy or coma)
• persistence or worsening in hypoxemia (PaO2<40mmHg) and/or respiratory acidosis (pH<7.25) despite oxygen supplementation or use of non-invasive ventilation
• hemodynamic instability requiring vasoactive drugs
• patients transferred to ICU
• hospitalization lower than 5 days
• diseases that prevented the exercises

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Fundação de Amparo à Pesquisa do Estado de São Paulo

OTHER_GOV

Sponsor Role: collaborator

University of Sao Paulo

OTHER

Sponsor Role: lead

Responsible Party

Celso Ricardo Fernandes de Carvalho

PhD in physiology

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Rodrigo C Borges, specialist

Role: STUDY_CHAIR

school of Medicine university of sao paulo

Locations

University Hospital of sao paulo

São Paulo, São Paulo, Brazil

Countries

Brazil

References

Borges RC, Carvalho CR. Impact of resistance training in chronic obstructive pulmonary disease patients during periods of acute exacerbation. Arch Phys Med Rehabil. 2014 Sep;95(9):1638-45. doi: 10.1016/j.apmr.2014.05.007. Epub 2014 May 28.

Reference Type: DERIVED

PMID: 24879965 (View on PubMed)

Other Identifiers

PTR-001-RCB

Identifier Type: -

Identifier Source: org_study_id