Effect and Feasibility of Non-linear Periodized Resistance Training in People With COPD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

57 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-04-16

Study Completion Date

2023-03-01

Brief Summary

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This study aims at improving the knowledge about resistance training for people with COPD. Resistance training is an important part of pulmonary rehabilitation when the goal is to improve muscular endurance and strength. The study will evaluate the effects and the feasibility of two resistance training programs for people with COPD using a parallel group design. One program will include a larger day-to-day variation (i.e. non-linear periodization) and the progression will be guided by ratings of dyspnea, muscle fatigue, and exertion. The other program will follow the established guidelines for resistance training for people with COPD. The programs will be evaluated for effects regarding muscular endurance, strength, intramuscular adaptions, functional preformance, dyspnea, and health related quality of life. The programs will also be evaluated for feasibility regarding the duration of training sessions, attendance rates, adverse events, and participant satisfaction. The hypothesis is that the non-linear periodization group will have superior effects and that feasibility aspects will be similar between groups.

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Detailed Description

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Conditions

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Pulmonary Disease Chronic Obstructive

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Prospective, assessor-blind, parallel-group randomized controlled multicenter trial with a pre- and post-intervention design

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

The outcome assessors will be masked to group allocation. The participants will be given repeated instructions not to reveal their group allocation to the outcome assessors. In case of failure in keeping the outcome assessor masked (i.e, a patient reveals his/her group allocation), a second trained outcome assessor will be available.

Study Groups

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Non-linear Periodized Resistance Training

The objective of the Non-linear Periodized Resistance Training (NLPRT) program is to increase muscle strength as well as muscle endurance. The NLPRT program will over the 8 week intervention period target several different aspects of limb muscle function, by alternating the intensity and volume of the exercises.

Progression of exercise is symptom dependent and will be based on Borg CR-10 ratings (dyspnea, muscle fatigue and exertion).

All exercises will be performed using exercise equipment that are available at each included center.

All sessions are supervised and conducted by local professionals using a group format, with approximately 2-4 participants per group.

Group Type EXPERIMENTAL

Non-linear Periodized Resistance Training

Intervention Type OTHER

8 week non-linear periodized resistance training intervention, 3 sessions per week, 60 minutes per session

Resistance Training

The primary objective of the Resistance training (RT) group is to increase muscular strength. The RT program will be performed in line with current guidelines that are recommended for increasing muscular strength in patients with COPD.

Progression of exercise is performance dependent and will be based on the previous 2 sessions.

All exercises will be performed using exercise equipment that are available at each included center.

All sessions are supervised and conducted by local professionals using a group format, with approximately 2-4 participants per group.

Group Type ACTIVE_COMPARATOR

Resistance training

Intervention Type OTHER

8 week resistance training intervention, 3 sessions per week, 60 minutes per session

Interventions

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Non-linear Periodized Resistance Training

8 week non-linear periodized resistance training intervention, 3 sessions per week, 60 minutes per session

Intervention Type OTHER

Resistance training

8 week resistance training intervention, 3 sessions per week, 60 minutes per session

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* FEV1/FVC ratio \< 70% postbronchodilator
* FEV1 \<80% of the predicted normal value postbronchodilator

Exclusion Criteria

* Clinical evidence of asthma, cardiovascular diseases, and/or neuromuscular diseases that are unstable and/or that may contribute to exercise limitation
* Other contraindications to exercise
* Currently participating in a structured exercise or pulmonary rehabilitation program or been involved in pulmonary rehabilitation in the past 6 months
* Experienced a COPD exacerbation and/or change in medication dosage/frequency in the past 6 weeks

Minimum Eligible Age

40 Years

Maximum Eligible Age

89 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No