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Exercise Training and Inflammatory Mediators in COPD

NCT ID: NCT03853174

Last Updated: 2019-12-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-01

Study Completion Date

2019-04-27

Brief Summary

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Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020\[1\]. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable\[2\].

Detailed Description

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Chronic obstructive pulmonary disease (COPD) is widely spread all over the world. It is predicted to be the third leading cause of death by 2020. COPD is a common, preventable treatable disease that is characterized by an airflow limitation which is not fully reversable.Not only the long-term exposition to noxious particles and gases contributes to the development of COPD, but also so many others factors such as genetics and cigarette smoking. It has been shown that cigarettes are harmful and contributed to different extra pulmonary disorders. Indeed, it induced a systemic inflammation that was considered as a key process in the pathogenesis of COPD and triggered the activation of inflammatory cells and an abnormal increase of circulating cytokines such as CRP, interleukin (IL6), IL8, tumor necrosis factor alpha (TNF alpha) and leptin.

Conditions

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COPD

Keywords

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COPD Inflammation exercise training

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Caregivers Investigators

Study Groups

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ET

Active Comparator: ET Endurance training were prformed. Intensity was gradually increased.

Group Type ACTIVE_COMPARATOR

Endurance Training ET

Intervention Type OTHER

Endurance training were prformed. Intensity was gradually increased.

RT

Resistance training were prformed. Intensity was gradually increased.

Group Type OTHER

Resistance Training RT

Intervention Type OTHER

Resistance training were prformed. Intensity was gradually increased.

Interventions

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Endurance Training ET

Endurance training were prformed. Intensity was gradually increased.

Intervention Type OTHER

Resistance Training RT

Resistance training were prformed. Intensity was gradually increased.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* COPD diagnosed by pulmonary function testing
* Clinically stable
* Abscence of other obstructive diseases
* Signed written consent

Exclusion Criteria

* Neuromuscular diseases -Severe psychiatric, neurologic or musculoskeletal conditions and /or instable--- --
* cardiovascular diseases.
* Contre-indications to physical therapy
* Acute exacerbations a month before the intervention
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Faculty of Medicine, Sousse

OTHER

Sponsor Role lead

Responsible Party

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Acheche Amal

PhD student

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Amal Acheche, Phd

Role: PRINCIPAL_INVESTIGATOR

Faculty of Medicine of Sousse Sousse, Tunisia

Locations

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Amal Acheche

Sousse, , Tunisia

Site Status

Countries

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Tunisia

References

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authors non mentionned., global initiative for chronic lung disease. 2017

Reference Type BACKGROUND

Molfino NA, Jeffery PK. Chronic obstructive pulmonary disease: histopathology, inflammation and potential therapies. Pulm Pharmacol Ther. 2007;20(5):462-72. doi: 10.1016/j.pupt.2006.04.003. Epub 2006 May 6.

Reference Type BACKGROUND
PMID: 16798034 (View on PubMed)

Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016 Jul;138(1):16-27. doi: 10.1016/j.jaci.2016.05.011. Epub 2016 May 27.

Reference Type BACKGROUND
PMID: 27373322 (View on PubMed)

Barnes PJ. Cellular and molecular mechanisms of chronic obstructive pulmonary disease. Clin Chest Med. 2014 Mar;35(1):71-86. doi: 10.1016/j.ccm.2013.10.004. Epub 2013 Dec 12.

Reference Type BACKGROUND
PMID: 24507838 (View on PubMed)

Other Identifiers

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COPD and exercise

Identifier Type: -

Identifier Source: org_study_id