Muscle Metabolism and Oxygenation During Localized Fatigue-exercise in COPD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to investigate whether a localized exercise, in which cardiorespiratory demand is reduced, will result in greater limb muscle fatigue in patients with COPD as a consequence of muscle oxygenation and muscle metabolism disturbances.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Impact of Muscle Afferent Feedback During Exercise in Patients With Chronic Obstructive Pulmonary Disease (COPD)

NCT01522729

Chronic Obstructive Pulmonary Disease

COMPLETED NA

The Effect of Respiratory Training on Exercise Tolerance in COPD

NCT04201522

Pulmonary Disease, Chronic Obstructive

UNKNOWN NA

The Effects of Physical Exercise Training in Patients With Chronic Obstructive Pulmonary Disease

NCT02050945

COPD Exercise Resistance Training

COMPLETED NA

Signaling Pathway Activation After Exercise in Patients With Chronic Obstructive Pulmonary Disease

NCT01561625

Chronic Obstructive Pulmonary Disease

COMPLETED NA

The Effect of a Respiratory Muscle Warm-up Prior to Exercise in Patients With Chronic Obstructive Pulmonary Disease

NCT02532075

Chronic Obstructive Pulmonary Disease

TERMINATED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pulmonary Disease, Chronic Obstructive

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Oxygen

Group Type EXPERIMENTAL

Fatiguing exercise

Intervention Type OTHER

All participants (patients and healthy subjects) will perform the exercise both under normoxic (FiO2 = 0.21) and hyperoxic conditions (FiO2 = 100%)

Room air

Group Type SHAM_COMPARATOR

Fatiguing exercise

Intervention Type OTHER

All participants (patients and healthy subjects) will perform the exercise both under normoxic (FiO2 = 0.21) and hyperoxic conditions (FiO2 = 100%)

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Fatiguing exercise

All participants (patients and healthy subjects) will perform the exercise both under normoxic (FiO2 = 0.21) and hyperoxic conditions (FiO2 = 100%)

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* COPD (FEV1/FVC \< 0.70 and FEV1 \< 0.80 predicted
* Healthy subjects: no evidence of airways obstruction (FEV1/FVC \> 0.70 and FEV1 \> 0.80 predicted)
* Smoking history \> 15 pack-years

Exclusion Criteria

* Chronic hypoxemia and/or hypercapnia (PaO2 \< 60 mmHg or SpO2 \< 88% at rest and/or PaCO2 \> 45 mmHg)
* Recent exacerbation (\< 3 months)
* Recent cancer (\< 3 years)
* Diabetes
* Myopathy, neuromuscular or articular disease
* Unstable cardiac disease
* Absolute contraindications to exercise testing
* Regular physical activity or exercise training program in the last 2 months
* Physical activity score \> 9 in the Voorips questionnaire
* Thigh skinfold thickness \> 15 mm
* BMI \> 30

Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes