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Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients

NCT ID: NCT01183052

Last Updated: 2012-09-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-06-30

Study Completion Date

2010-12-31

Brief Summary

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The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.

Detailed Description

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Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.

Conditions

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COPD Patients

Keywords

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COPD exercise tolerance oxidative stress

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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Training

20 sessions of training

Group Type OTHER

Training

Intervention Type OTHER

20 sessions of training

Interventions

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Training

20 sessions of training

Intervention Type OTHER

Other Intervention Names

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CT

Eligibility Criteria

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Inclusion Criteria

* Sedentary mild to severe COPD patients

Exclusion Criteria

* Neuromuscular disease
* Chronic heart failure
* Renal diseases
* Liver diseases
* Obesity
Minimum Eligible Age

50 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Régional Universitaire Montpellier

OTHER

Sponsor Role collaborator

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role collaborator

5 Santé

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Maurice MH Hayot, MCU-PH

Role: PRINCIPAL_INVESTIGATOR

Institut National de la Santé Et de la Recherche Médicale, France

Locations

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Clinique du Souffle La Vallonie

Lodève, , France

Site Status

Clinique du Souffle la Solane

Osséja, , France

Site Status

Countries

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France

Other Identifiers

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2009-A00426-51

Identifier Type: -

Identifier Source: org_study_id