Involvement of Nervous System in Muscle Weakness in COPD Patients

NCT ID: NCT01679782

Last Updated: 2015-03-10

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 137 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-07-31
• Study Completion Date: 2014-04-30

Brief Summary

The purpose of this study is to determine whether nervous system alterations and motor drive failure can contribute to muscle weakness in COPD during voluntary movement. If necessary, we will look after the role of nocturnal hypoxia in these alterations.

Detailed Description

COPD is a common disease that induces many systemic repercussions. Among these, peripheral muscle dysfunction is particularly deleterious because it leads to the decreases of the level of activity and the quality of life for patients. Movement involves activation of many structures, from the instructor, i.e. the brain, to the effector, i.e. the muscle. Netherless, the studies which have described peripheral muscle dysfunction have been focused on the muscle, so they have proposed a reducing vision of the phenomenon. Other studies have reported cerebral alterations in COPD, like cognitive disturbance, increase of the neuronal conduction time, and decrease of the white matter density, and were associated with chronic hypoxemia. Such alterations are consistent with the existence of a decrease of the central motor drive during voluntary movement in COPD patients. Therefore the study will aim to determine precisely which mechanisms are involved in peripheral muscle dysfunction in copd.

Conditions

Chronic Obstructive Pulmonary Disease

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

COPD nocturnal desaturator

COPD patients who spend 30% of the nigth with a SaO2 \< 90%.

No interventions assigned to this group

COPD no nocturnal desaturator

COPD patients who spend less than 30% of the night with a SaO2 \< 90%

No interventions assigned to this group

control group

healthy sedentary subjects

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• COPD Patients at stage 2 and 3
• Healthy sedentary subjects

Exclusion Criteria

• Epilepsy, pace-maker, nervous disorders

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 75 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

M2H laboratory, Montpellier University

OTHER

Sponsor Role: collaborator

ANRT, National French Agency for Technological Researches

UNKNOWN

Sponsor Role: collaborator

5 Santé

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Alain AV Varray, Pr

Role: STUDY_DIRECTOR

M2H laboratory, Montpellier

Locations

Clinique du Souffle La Vallonie

Lodève, , France

Countries

France

References

Alexandre F, Heraud N, Sanchez AM, Tremey E, Oliver N, Guerin P, Varray A. Brain Damage and Motor Cortex Impairment in Chronic Obstructive Pulmonary Disease: Implication of Nonrapid Eye Movement Sleep Desaturation. Sleep. 2016 Feb 1;39(2):327-35. doi: 10.5665/sleep.5438.

Reference Type: DERIVED

PMID: 26446126 (View on PubMed)

Other Identifiers

FVIE_FA1

Identifier Type: -

Identifier Source: org_study_id