Acute Effects of Supramaximal High-Intensity Interval Training in People With COPD

NCT ID: NCT05874999

Last Updated: 2023-06-07

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 32 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-03-07
• Study Completion Date: 2022-12-22

Brief Summary

High-intensity exercise is essential for optimal development of cardiorespiratory fitness and health. This is, however, challenging for most people with chronic obstructive pulmonary disease (COPD) due to ventilatory limitations, leading to exercise at lower intensities accompanied by suboptimal stress on the cardiovascular and muscular system.

The aims of this cross-over trial is:

1. To compare the acute effects of short-duration supramaximal high-intensity interval training (HIIT) vs. traditional moderate-intensity continuous training (MICT) in people with COPD and matched healthy controls (HC).

2. To investigate the feasibility of supramaximal HIIT in people with COPD and matched HC.

3. To compare the cardiorespiratory demand, exercise intensity and symptoms during a modified Borg Cycle Strength Test (BCST) and a cardiopulmonary exercise test (CPET) in people with COPD and HC.

Detailed Description

In this study, eligible participants attended the facility four times within 14 days with at least 48 hours of rest between visits.

Exercise tests (visit 1, week 1):

After pulmonary functions tests, a CPET on a stationary bicycle was performed according to international guidelines. After 1.5 hours of recovery, a BCST was performed to assess anaerobic exercise capacity and determine exercise intensities for supramaximal HIIT.

Exercise sessions (visit 2 - week 1; visit 3 - week 2; visit 4 - week 2):

The order of the two first exercise sessions (HIIT at 60% of MPO6 or MICT) on a stationary bicycle were randomized. The exercise session at HIIT at 80% of MPO6 was always the third exercise session.

During all exercise sessions, blood collection was performed at baseline after a 15-minute seated rest. During HIIT, blood was collected immediately after, and 30 minutes after the 10-minute HIIT period. For MICT, blood was collected after 10 minutes (isotime in relation to HIIT), immediately after, and 30 minutes of cycling at 60% MAP.

Conditions

COPD; Healthy Older Adults

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Chronic Obstructive Pulmonary Disease (COPD)

People with chronic obstructive pulmonary disease (COPD) (n = 16)

Group Type: EXPERIMENTAL

Supramaximal High-Intensity Interval Training at 60% of MPO6

Intervention Type: OTHER

Supramaximal HIIT is performed as 10×6 second intervals against a load of 60% of maximum mean power output for 6 seconds (MPO6) with a 54 second recovery between intervals. The MPO6 was estimated from the BCST.

Duration supramaximal HIIT: 10 minutes

Warm-up and cool-down: 5 minutes at 30% of maximum aerobic power (MAP) obtained during maximal incremental cardiopulmonary exercise test (CPET) on a stationary bicycle.

Moderate-Intensity Continuous Training

Intervention Type: OTHER

MICT is performed against a load of 60% of MAP obtained during a maximal incremental CPET on a stationary bicycle.

Duration MICT: 20 minutes

Warm-up and cool-down: 5 minutes at 30% of MAP obtained during maximal incremental CPET on a stationary bicycle.

Supramaximal High-Intensity Interval Training at 80% of MPO6

Intervention Type: OTHER

Supramaximal HIIT is performed as 10×6 second intervals against a load of 80% of MPO6 with a 54 second recovery between intervals. The MPO6 was estimated from the BCST.

Duration supramaximal HIIT: 10 minutes

Warm-up and cool-down: 5 minutes at 30% of MAP obtained during maximal incremental CPET on a stationary bicycle.

Healthy Controls (HC)

Healthy controls matched on age, sex and objectively measured physical activity (n = 16)

Group Type: ACTIVE_COMPARATOR

Supramaximal High-Intensity Interval Training at 60% of MPO6

Intervention Type: OTHER

Supramaximal HIIT is performed as 10×6 second intervals against a load of 60% of maximum mean power output for 6 seconds (MPO6) with a 54 second recovery between intervals. The MPO6 was estimated from the BCST.

Duration supramaximal HIIT: 10 minutes

Warm-up and cool-down: 5 minutes at 30% of maximum aerobic power (MAP) obtained during maximal incremental cardiopulmonary exercise test (CPET) on a stationary bicycle.

Moderate-Intensity Continuous Training

Intervention Type: OTHER

MICT is performed against a load of 60% of MAP obtained during a maximal incremental CPET on a stationary bicycle.

Duration MICT: 20 minutes

Warm-up and cool-down: 5 minutes at 30% of MAP obtained during maximal incremental CPET on a stationary bicycle.

Supramaximal High-Intensity Interval Training at 80% of MPO6

Intervention Type: OTHER

Supramaximal HIIT is performed as 10×6 second intervals against a load of 80% of MPO6 with a 54 second recovery between intervals. The MPO6 was estimated from the BCST.

Duration supramaximal HIIT: 10 minutes

Warm-up and cool-down: 5 minutes at 30% of MAP obtained during maximal incremental CPET on a stationary bicycle.

Interventions

Supramaximal High-Intensity Interval Training at 60% of MPO6

Supramaximal HIIT is performed as 10×6 second intervals against a load of 60% of maximum mean power output for 6 seconds (MPO6) with a 54 second recovery between intervals. The MPO6 was estimated from the BCST.

Duration supramaximal HIIT: 10 minutes

Warm-up and cool-down: 5 minutes at 30% of maximum aerobic power (MAP) obtained during maximal incremental cardiopulmonary exercise test (CPET) on a stationary bicycle.

Intervention Type: OTHER

Moderate-Intensity Continuous Training

MICT is performed against a load of 60% of MAP obtained during a maximal incremental CPET on a stationary bicycle.

Duration MICT: 20 minutes

Warm-up and cool-down: 5 minutes at 30% of MAP obtained during maximal incremental CPET on a stationary bicycle.

Intervention Type: OTHER

Supramaximal High-Intensity Interval Training at 80% of MPO6

Supramaximal HIIT is performed as 10×6 second intervals against a load of 80% of MPO6 with a 54 second recovery between intervals. The MPO6 was estimated from the BCST.

Duration supramaximal HIIT: 10 minutes

Warm-up and cool-down: 5 minutes at 30% of MAP obtained during maximal incremental CPET on a stationary bicycle.

Intervention Type: OTHER

Other Intervention Names

Supramaximal High-Intensity Interval Training at 60% of MPO6 (HIIT60%); MICT; Supramaximal High-Intensity Interval Training at 80% of MPO6 (HIIT80%)

Eligibility Criteria

Inclusion Criteria

• COPD with non-reversible airflow obstruction diagnosis (post-bronchodilator forced expiratory volume during the first second/forced vital capacity (FEV1/FVC) < 0.7)
• Age: > 40 years

• Age: > 40 years

Exclusion Criteria

• Recent exacerbation of COPD (< 6 weeks)
• Neuromuscular, orthopaedic and/or any other condition that can compromise participation in testing
• Recent lung cancer (< 5 years)
• Unstable cardiac disease and/or cardiac stimulator

HC

• Neuromuscular, orthopaedic and/or any other condition that can compromise participation in testing
• Any respiratory disease
• Recent lung cancer (< 5 years)
• Unstable cardiac disease and/or cardiac stimulator
• Too low or high physical activity level that prohibits matching

• Minimum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

The Swedish Research Council

OTHER_GOV

Sponsor Role: collaborator

Swedish Heart Lung Foundation

OTHER

Sponsor Role: collaborator

Riksförbundet HjärtLung

UNKNOWN

Sponsor Role: collaborator

Umeå University

OTHER

Sponsor Role: lead

Responsible Party

Andre Nyberg

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Andre Nyberg, PhD

Role: PRINCIPAL_INVESTIGATOR

Umeå University

Locations

Umeå University

Umeå, , Sweden

Countries

Sweden

Other Identifiers

COPD-HIIT ACUTE

Identifier Type: -

Identifier Source: org_study_id