Effects of HIIT in Tolerance to Exercise of Individuals With HF and Coexisting COPD

NCT ID: NCT04350541

Last Updated: 2021-10-12

Basic Information

• Recruitment Status: SUSPENDED
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-09-01
• Study Completion Date: 2021-12-15

Brief Summary

INTRODUCTION: The complexity of the pathophysiology of heterogeneous diseases such as heart failure and obstructive pulmonary disease causes a different approach to these diseases or with a view as much as a better understanding of the same situations, with which the clinical profile of patients who are associated with an association is. It is known that regular physical training promotes progressive improvements in exercise tolerance, in the pulmonary ventilation / perfusion ratio and in respiratory function by strengthening. OBJECTIVE: To compare the effects of high-intensity interval training and continuous aerobic exercise, with peripheral endothelial function, brain natriuretic peptide levels, maximum exercise tolerance, distribution of lung volumes and quality of life of patients with obstructive pulmonary disease associated with heart failure. METHODS: This is a clinical, controlled, randomized and blinded trial. Peripheral endothelial function, tolerance to maximum and submaximal exercise, distribution of lung volumes, quality of life, presence of symptoms of depression and perception of clinical change will be evaluated. EXPECTED RESULTS: Incorporate into the care of these patients, new effective therapeutic approaches, of low cost and with greater technical and scientific evidence.

Conditions

Heart Failure; Chronic Obstructive Pulmonary Disease

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Interval training

Interval training will consist of 10 minutes of warm-up between 40-50% of the peak oxygen consumption (VO2peak), followed by four to six repetitions of three-minute intervals between 80-90% of VO2peak and three minutes between 40-50% VO2peak and finally, five minutes of cooling down between 30-40% of VO2peak.

Group Type: EXPERIMENTAL

High-intensity interval training

Intervention Type: OTHER

Exercise with high-intensity intervals followed by active rest

Continuous training

The continuous aerobic training will consist of 10 minutes of warm-up with intensity between 40 and 50% of VO2peak, 20 minutes of conditioning between 60 and 70% of VO2peak and 5 minutes of cooling down between 30 and 40% of VO2peak.

Group Type: ACTIVE_COMPARATOR

Continuous aerobic training

Intervention Type: OTHER

Interval Moderate-intensity aerobic training without intervals

Interventions

High-intensity interval training

Exercise with high-intensity intervals followed by active rest

Intervention Type: OTHER

Continuous aerobic training

Interval Moderate-intensity aerobic training without intervals

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Sedentary individuals with Heart Failure of all etiologies;
• Diagnosed moderate and severe chronic obstructive pulmonary disease;
• Clinical stability;
• No change in the medication class within three months before the beginning of the research.

Exclusion Criteria

• Unstable angina;
• Myocardial infarction;
• Previous cardiac surgery up to three months before the beginning of the study;
• Hemodynamic instability;
• Orthopedic and neurological diseases;
• Psychological and/or mental impairment.

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Universidade Federal de Pernambuco

OTHER

Sponsor Role: lead

Responsible Party

BRUNA THAYS SANTANA DE ARAÚJO

physiotherapist, clinical research

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Federal University of Pernambuco

Recife, Pernambuco, Brazil

Countries

Brazil

Other Identifiers

07640919.4.0000.5208

Identifier Type: -

Identifier Source: org_study_id