The Effect of Breathing Helium-Hyperoxia During Pulmonary Rehabilitation in Patients With COPD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-03-31

Study Completion Date

2007-01-31

Brief Summary

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The purpose of this study is to examine whether breathing helium-hyperoxia during exercise in a pulmonary rehabilitation program can improve the exercise tolerance and health related quality of life of patients with Chronic Obstructive Pulmonary Disease (COPD).

Detailed Description

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It is well accepted that the exercise training as part of a comprehensive pulmonary rehabilitation program can improve exercise tolerance, functional status and quality of life in patients with COPD. It is feasible that if patients were able to perform a greater volume or intensity of exercise during rehabilitation then the outcomes of the program would be improved. Recent research has demonstrated that breathing a helium-hyperoxic gas mixture can significantly reduce dynamic hyperinflation and dyspnea during exercise in patients with COPD and can increase exercise tolerance to a greater extent than breathing room air or a nitrogen-based hyperoxic gas. If patients with COPD were to breathe a helium-hyperoxic gas during exercise they should be able to tolerate a greater intensity of exercise while maintaining similar levels of exertional symptoms to those observed at lower exercise intensities breathing room air. As a result patients randomized to the helium-hyperoxia condition should obtain greater improvements in exercise tolerance than those receiving usual care (i.e. breathing room air)

Comparisons: Standard pulmonary rehabilitation of patients with COPD receiving either usual care (air breathing) or helium-hyperoxia (40% O2, 60% Helium).

Conditions

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Chronic Obstructive Pulmonary Disease COPD Emphysema Lung Diseases Bronchitis, Chronic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Helium-Hyperoxia

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* FEV1/FVC\<70% predicted;
* FEV1\<70% predicted;
* RV\>140% predicted.

Exclusion Criteria

* Cardiovascular contraindications to exercise;
* Musculoskeletal abnormalities that limit exercise tolerance;
* SpO2\<85% during a constant work rate test;
* On supplemental oxygen.
* Exacerbation within the last month

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Principal Investigators

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Neil D Eves, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Calgary, AB, Canada

Locations

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Caritas Centre for Lung Health

Edmonton, Alberta, Canada

Site Status

Countries

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Canada

References

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Eves ND, Petersen SR, Haykowsky MJ, Wong EY, Jones RL. Helium-hyperoxia, exercise, and respiratory mechanics in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006 Oct 1;174(7):763-71. doi: 10.1164/rccm.200509-1533OC. Epub 2006 Jul 13.

Reference Type BACKGROUND

PMID: 16840742 (View on PubMed)

Eves ND, Sandmeyer LC, Wong EY, Jones LW, MacDonald GF, Ford GT, Petersen SR, Bibeau MD, Jones RL. Helium-hyperoxia: a novel intervention to improve the benefits of pulmonary rehabilitation for patients with COPD. Chest. 2009 Mar;135(3):609-618. doi: 10.1378/chest.08-1517. Epub 2008 Nov 18.

Reference Type DERIVED

PMID: 19017883 (View on PubMed)

Other Identifiers

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MSI 824

Identifier Type: -

Identifier Source: org_study_id