Subcision Followed by Diluted Calcium Hydroxylapatite Injection Versus Subcision Followed by Painting CROSS TCA Technique for the Treatment of Atrophic Acne Scars

NCT ID: NCT07028567

Last Updated: 2025-06-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 13 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-01-01
• Study Completion Date: 2023-06-22

Brief Summary

This study aimed to compare the safety and efficacy of subcision followed by diluted calcium hydroxyapatite injection versus subcision followed by the painting original chemical reconstruction of skin scars (CROSS) technique using trichloroacetic acid (TCA) for the treatment of atrophic acne scars.

Detailed Description

Atrophic scars present as depressions secondary to fibrous contractions. Subcision is a technique in which a needle is inserted under the acne scar to sever the fibrous tissue (tethers) that bind down the scar. This releases the fibrous tissue.

The original chemical reconstruction of skin scars (CROSS) technique using trichloroacetic acid (TCA) entails focal application of highly concentrated TCA (70% to 100%) with firm pressure applied to the entire atrophic area using a sharpened wooden applicator until frosting occurs.

Fillers containing hyaluronic acid, calcium hydroxyapatite, and poly-L-lactic acid are increasingly used to correct atrophic acne scarring as they augment soft tissue in variable degree and are most effective in soft rolling or boxcar scars.

Conditions

Subcision; Calcium Hydroxylapatite; Trichloroacetic Acid; Atrophic Acne Scar

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Study group

Patients with atrophic acne scars.

Group Type: EXPERIMENTAL

Calcium hydroxylapatite filler

Intervention Type: DRUG

Patients received calcium hydroxylapatite filler (CaHA) (Radiesse®).

Painting chemical reconstruction of skin scars trichloroacetic acid technique

Intervention Type: DRUG

Patients received painting chemical reconstruction of skin scars (CROSS) trichloroacetic acid (TCA) technique.

Interventions

Calcium hydroxylapatite filler

Patients received calcium hydroxylapatite filler (CaHA) (Radiesse®).

Intervention Type: DRUG

Painting chemical reconstruction of skin scars trichloroacetic acid technique

Patients received painting chemical reconstruction of skin scars (CROSS) trichloroacetic acid (TCA) technique.

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Age from 20 to 50 years.
• Both sexes.
• Patients with atrophic acne scars.

Exclusion Criteria

• Patients with Fitzpatrick skin phototypes V and VI.
• Receiving systemic isotretinoin medication at the time of the study.
• Active bacterial, viral or fungal infections in the treatment area.
• Hypertrophic scarring or keloidal tendency.
• Photosensitivity or photodermatitis.
• Unrealistic expectation, bleeding, coagulation disorders, and any other related skin disease.
• Pregnant or lactating females.
• Chronic debilitating diseases such as diabetes mellitus, cardiovascular diseases, renal failure, hepatic diseases, chronic respiratory diseases or any endocrine diseases.
• History of immunosuppressive drug intake or chemotherapy within 6 months before treatment.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tanta University

OTHER

Sponsor Role: lead

Responsible Party

Riham Mohamed ElSayed ElSetiha

Resident of Dermatology and Venereology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Tanta University

Tanta, El-Gharbia, Egypt

Countries

Egypt

Other Identifiers

36195/12/22

Identifier Type: -

Identifier Source: org_study_id