The Efficacy of Combination Therapy in Atrophic Scars

NCT ID: NCT06298591

Last Updated: 2024-03-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-15

Study Completion Date

2027-03-15

Brief Summary

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There are more than 100 million patients who develop scar formation caused by various factors, such as post-inflammatory acne and trauma (1). They often have physical, aesthetic, psychological, and social barriers. Scar tissue is naturally a stage of wound healing. Abnormal wound healing produces a spectrum of scar tissue types such as atrophic, hypertrophic, and keloid scars (2).

Atrophic scars are dermal depressions, which are commonly caused by the destruction of collagen following inflammatory process. This permanent disfiguring sequelae correlates with the duration of pathology, severity of lesion, and delay in therapy (3).

Treatment of atrophic acne scars remains a therapeutic challenge, yet there is no standard option as the most effective treatment (4). A range of possible options has been investigated including surgical techniques (subcision, non-ablative laser treatment, resurfacing techniques (ablative laser treatment, dermabrasion), and injection or dermal fillers or fat, and a combination of two or more modalities (5).

Ultrasound is a unique non-invasive and non-radiating medical imaging tool in the investigation of dermatological diseases by providing detailed anatomic and physiologic data of skin lesions and deeper soft tissue changes. Lesion size in three dimensions-lengths, width, and depth, morphology, the detailed anatomic information provided by sonography is useful to assessment of effect of different types of treatment modality to improve atrophic scar and avoid invasive assessment tools as punch biopsy for histopathological examination (6)

Detailed Description

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atrophic scar mangment

Conditions

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Atrophic Scar

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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subcision

Group Type OTHER

co2 laser

Intervention Type PROCEDURE

laser

Interventions

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co2 laser

laser

Intervention Type PROCEDURE

Other Intervention Names

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fractional co2 laser

Eligibility Criteria

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Inclusion Criteria

\- Patients aged from 12 to 60 years with

* post inflammatory atrophic scar.
* post traumatic atrophic scar.
* post operative atrophic scar

Exclusion Criteria

* post acne scar.
* active skin infection.
Minimum Eligible Age

12 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Ali Ahmed Hasan

Assistant Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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atrophic scar treatment

Identifier Type: -

Identifier Source: org_study_id

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