Efficacy of Stromal Vascular Fraction on Acne Scar Correction
NCT ID: NCT07094958
Last Updated: 2025-07-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
16 participants
INTERVENTIONAL
2025-07-31
2026-07-31
Brief Summary
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In this prospective, randomized, split-face clinical trial, participants with atrophic acne scars will receive SVF injections on one side of the face and normal saline (NS) injections on the contralateral side as a control. Clinical efficacy will be assessed through blinded scar counts, digital imaging, and histological evaluations including epidermal and dermal regenerative markers. The study is designed to investigate whether SVF provides superior clinical improvement compared to placebo.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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SVF-treated side
Intradermal injection of autologous stromal vascular fraction (SVF) on one side of the face.
stromal vascular fraction (SVF)
Autologous stromal vascular fraction (SVF) isolated from adipose tissue was injected intradermally into one side of the face to evaluate its efficacy in treating atrophic acne scars. SVF was freshly prepared on the same day of injection using enzymatic digestion and centrifugation.
Saline-treated side
Intradermal injection of normal saline (NS) on the contralateral side of the face.
Normal Saline (NS)
Normal saline (NS) was injected intradermally into the contralateral side of the face and served as a placebo comparator to SVF in this split-face study on atrophic acne scars.
Interventions
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stromal vascular fraction (SVF)
Autologous stromal vascular fraction (SVF) isolated from adipose tissue was injected intradermally into one side of the face to evaluate its efficacy in treating atrophic acne scars. SVF was freshly prepared on the same day of injection using enzymatic digestion and centrifugation.
Normal Saline (NS)
Normal saline (NS) was injected intradermally into the contralateral side of the face and served as a placebo comparator to SVF in this split-face study on atrophic acne scars.
Eligibility Criteria
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Inclusion Criteria
* Presence of bilateral atrophic acne scars (boxcar, rolling, or icepick types) on the face
* Willingness to undergo fat harvesting procedure
* Ability to comply with study visits and follow-up
* Written informed consent obtained
Exclusion Criteria
* History of keloid or hypertrophic scarring
* Prior treatment for acne scars (e.g., laser, filler, microneedling) within the past 6 months
* History of systemic immunosuppressive therapy within the past 3 months
* Pregnant or breastfeeding women
* Any systemic disease that may interfere with wound healing or safety assessment (e.g., uncontrolled diabetes, collagen vascular disease)
19 Years
45 Years
ALL
No
Sponsors
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Seoul National University Hospital
OTHER
Responsible Party
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Dae Hun Suh
Professor
Central Contacts
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References
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Mbiine R, Wayengera M, Kiwanuka N, Munabi I, Muwonge H, Nakanwagi C, Joloba M, Galukande M. Autologous adipose-derived stromal vascular fraction (SVF) in scar treatment among patients with keloids and hypertrophic scars: a systematic review and meta-analysis of current practices and outcomes. Am J Stem Cells. 2023 Dec 15;12(5):98-111. eCollection 2023.
Bora P, Majumdar AS. Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation. Stem Cell Res Ther. 2017 Jun 15;8(1):145. doi: 10.1186/s13287-017-0598-y.
Connolly D, Vu HL, Mariwalla K, Saedi N. Acne Scarring-Pathogenesis, Evaluation, and Treatment Options. J Clin Aesthet Dermatol. 2017 Sep;10(9):12-23. Epub 2017 Sep 1.
Dreno B, Layton A, Bettoli V et al. Evaluation of the prevalence, risk factors, clinical characteristics, and burden of acne scars among active acne patients in brazil, france, and the USA. J Am Acad Dermatol 2017; 76:ab132.
Kwon HH, Yoon HS, Suh DH, Yoon JY, Park SK, Lee ES, Lee JH, Kim NI, Kye YC, Ro YS, Lee SJ, Kim MN, Sung KJ, Lee ES, Kim KJ; Korean Society for Acne Research. A nationwide study of acne treatment patterns in Korea: analysis of patient preconceived notions and dermatologist suggestion for treatment. Acta Derm Venereol. 2012 May;92(3):236-40. doi: 10.2340/00015555-1331.
Eichenfield DZ, Sprague J, Eichenfield LF. Management of Acne Vulgaris: A Review. JAMA. 2021 Nov 23;326(20):2055-2067. doi: 10.1001/jama.2021.17633.
Other Identifiers
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Acne scar_SVF study
Identifier Type: -
Identifier Source: org_study_id
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