Botulinum Toxin and Mesotherapy on Enhancement of Facial Scarring

NCT ID: NCT06562023

Last Updated: 2024-08-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-11-19

Study Completion Date

2024-07-20

Brief Summary

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Most of the body's tissues can undergo wound repair following a disruption of tissue integrity. Upon healing, these wounds result in scar formation. The scars widen when the overlying musculature pulls apart suture lines. Botulinum Toxin A (BTA) is known to prevent fibroblast proliferation and it also induces temporary muscle paralysis. Also, mesotherapy is the non-invasive transdermal injection which can aid the skin to increase collagen and elastin production. Thus, both techniques are eligible for enhancement of facial scars.

Detailed Description

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Conditions

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Facial Scars

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Caregivers Outcome Assessors

Study Groups

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BTA injection

Group Type EXPERIMENTAL

Botulinum Toxin Type A

Intervention Type OTHER

Patients will receive BTA injection within a period of 5 days after primary closure.

Mesotherapy

Group Type EXPERIMENTAL

Mesotherapy

Intervention Type OTHER

Patients will receive mesotherapy growth factor serum with a derma pen within a period of 5 days after primary closure.

Control

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Botulinum Toxin Type A

Patients will receive BTA injection within a period of 5 days after primary closure.

Intervention Type OTHER

Mesotherapy

Patients will receive mesotherapy growth factor serum with a derma pen within a period of 5 days after primary closure.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patient suffering from vertical or oblique forehead lacerations caused by trauma.
* Recent and fresh wounds.
* Atrophic scar (linear scar).

Exclusion Criteria

* Infected wound.
* Patient on chemotherapy treatment and history of malignancy.
* Patients suffering from burns on the forehead or complicated lacerations.
* Allergy to drugs used in this study
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hams Hamed Abdelrahman

OTHER

Sponsor Role lead

Responsible Party

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Hams Hamed Abdelrahman

Assistant Lecturer of Dental Public Health and biostatistical consultanat

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University

Alexandria, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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0926-5/2024

Identifier Type: -

Identifier Source: org_study_id

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