Microneedling Versus Carboxytherapy in Stria Distensae Rubra

NCT ID: NCT07001644

Last Updated: 2025-06-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-10-01

Study Completion Date

2025-12-31

Brief Summary

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The aim of this study is to evaluate and compare the efficacy and safety of microneedling and carboxytherapy either with or without platelet-rich plasma in the treatment of striae distensae rubra.

Detailed Description

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Conditions

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Striae Distensae

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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treated with microneedling

microneedling with topical application of PRP on one side of abdomen and microneedling only on the other side

Group Type ACTIVE_COMPARATOR

microneedling

Intervention Type DEVICE

microneedling with topical application of PRP on one side of abdomen and microneedling only on the other side.

treated with carboxytherapy

carboxytherapy with intradermal injection of PRP on one side of abdomen and carboxytherapy only on the other side

Group Type ACTIVE_COMPARATOR

Carboxytherapy

Intervention Type DEVICE

carboxytherapy with intradermal injection of PRP on one side of abdomen and carboxytherapy only on the other side.

Interventions

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microneedling

microneedling with topical application of PRP on one side of abdomen and microneedling only on the other side.

Intervention Type DEVICE

Carboxytherapy

carboxytherapy with intradermal injection of PRP on one side of abdomen and carboxytherapy only on the other side.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Female patients.
* Age ranging from 18-45 years old.
* Fitzpatrick skin type III-IV.
* Striae distensae rubra on the abdomen (bilateral and more or less symmetrical).

Exclusion Criteria

* Patients taking immunosuppressants or having any disease affecting wound healing including diabetes.
* Patients receiving systemic glucocorticoids for chronic health conditions.
* Patients with chronic dermatologic diseases such as psoriasis and vitiligo.
* Pregnant and lactating females.
* Patients with a tendency for keloid formation.
* Patients with endocrine disturbance.
* Patients with autoimmune diseases, systemic diseases such as severe anemia, respiratory, cardiac, renal or liver disorder.
* Patients with bleeding and coagulation disorders.
* Patients who received any form of treatment for their SD in the past 6 months.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Alexandria University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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professor doctor Amira Eid

Role: PRINCIPAL_INVESTIGATOR

Alexandria University

Locations

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Alexandria Faculty of Medicine

Alexandria, , Egypt

Site Status

Countries

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Egypt

Other Identifiers

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0107162

Identifier Type: -

Identifier Source: org_study_id

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